Tissue expression of TMEM59L - Summary - The Human Protein Atlas

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TMEM59L

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TMEM59L
Gene description	Transmembrane protein 59-like
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:	Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)

Protein evidence

Evidence at transcript level

Protein expression

Cytoplasmic expression with a granular pattern in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA010661
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus, pituitary gland)

GENE INFORMATION
Gene name	TMEM59L (HGNC Symbol)
Synonyms	BSMAP, C19orf4
Description	Transmembrane protein 59-like (HGNC Symbol)
Entrez gene summary	This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18607430 - 18621039
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000105696 (version 83.38)
Entrez gene	25789
UniProt	Q9UK28 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UK28
Antibodypedia	TMEM59L antibodies

PROTEIN BROWSER

TMEM59L-001	TMEM59L-005	TMEM59L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM59L-001 ENSP00000470879 ENST00000600490	Q9UK28 [Direct mapping] Transmembrane protein 59-like A0A024R7L4 [Target identity:100%; Query identity:100%] Chromosome 19 open reading frame 4, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	342 aa 37.6 kDa	Yes	1
TMEM59L-005 ENSP00000471612 ENST00000594709	M0R134 [Direct mapping] Transmembrane protein 59-like Show all	Predicted intracellular proteins Show all		134 aa 14.3 kDa	No	0
TMEM59L-201 ENSP00000262817 ENST00000262817	Q9UK28 [Direct mapping] Transmembrane protein 59-like A0A024R7L4 [Target identity:100%; Query identity:100%] Chromosome 19 open reading frame 4, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000139 [Golgi membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	342 aa 37.6 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.