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This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003073 [regulation of systemic arterial blood pressure] GO:0003214 [cardiac left ventricle morphogenesis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005977 [glycogen metabolic process] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007399 [nervous system development] GO:0007568 [aging] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010905 [negative regulation of UDP-glucose catabolic process] GO:0016055 [Wnt signaling pathway] GO:0019901 [protein kinase binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0030877 [beta-catenin destruction complex] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0032007 [negative regulation of TOR signaling] GO:0032869 [cellular response to insulin stimulus] GO:0034236 [protein kinase A catalytic subunit binding] GO:0036016 [cellular response to interleukin-3] GO:0036498 [IRE1-mediated unfolded protein response] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045719 [negative regulation of glycogen biosynthetic process] GO:0045732 [positive regulation of protein catabolic process] GO:0045823 [positive regulation of heart contraction] GO:0046325 [negative regulation of glucose import] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050321 [tau-protein kinase activity] GO:0061052 [negative regulation of cell growth involved in cardiac muscle cell development] GO:0071879 [positive regulation of adrenergic receptor signaling pathway] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1903146 [regulation of mitophagy] GO:1903955 [positive regulation of protein targeting to mitochondrion] GO:1904227 [negative regulation of glycogen synthase activity, transferring glucose-1-phosphate] GO:2000077 [negative regulation of type B pancreatic cell development] GO:2000171 [negative regulation of dendrite development] GO:2000466 [negative regulation of glycogen (starch) synthase activity] GO:2000467 [positive regulation of glycogen (starch) synthase activity]