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A majority of cancer cells displayed weak to moderate membranous and cytoplasmic immunoreactivity. Most gliomas, urothelial and renal cancers were negative.
Most cancer cells showed strong cytoplasmic and nuclear staining.
GENE INFORMATION
Gene name
GSK3A
Synonyms
Description
Glycogen synthase kinase 3 alpha (HGNC Symbol)
Entrez gene summary
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003073 [regulation of systemic arterial blood pressure] GO:0003214 [cardiac left ventricle morphogenesis] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005977 [glycogen metabolic process] GO:0006468 [protein phosphorylation] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007399 [nervous system development] GO:0007568 [aging] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010905 [negative regulation of UDP-glucose catabolic process] GO:0016055 [Wnt signaling pathway] GO:0019901 [protein kinase binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0030877 [beta-catenin destruction complex] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0032007 [negative regulation of TOR signaling] GO:0032869 [cellular response to insulin stimulus] GO:0034236 [protein kinase A catalytic subunit binding] GO:0036016 [cellular response to interleukin-3] GO:0036498 [IRE1-mediated unfolded protein response] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0045719 [negative regulation of glycogen biosynthetic process] GO:0045732 [positive regulation of protein catabolic process] GO:0045823 [positive regulation of heart contraction] GO:0046325 [negative regulation of glucose import] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050321 [tau-protein kinase activity] GO:0061052 [negative regulation of cell growth involved in cardiac muscle cell development] GO:0071879 [positive regulation of adrenergic receptor signaling pathway] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1903146 [regulation of mitophagy] GO:1903955 [positive regulation of protein targeting to mitochondrion] GO:1904227 [negative regulation of glycogen synthase activity, transferring glucose-1-phosphate] GO:2000077 [negative regulation of type B pancreatic cell development] GO:2000171 [negative regulation of dendrite development] GO:2000466 [negative regulation of glycogen (starch) synthase activity] GO:2000467 [positive regulation of glycogen (starch) synthase activity]