Expression of ATP13A1 in cancer - Summary - The Human Protein Atlas

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ATP13A1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATP13A1
Gene description	ATPase type 13A1
Protein class	Plasma proteins Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA031798 , HPA049717
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031798	HPA049717

GENE INFORMATION
Gene name	ATP13A1 (HGNC Symbol)
Synonyms	ATP13A, CGI-152, FLJ31858, KIAA1825
Description	ATPase type 13A1 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	19645198 - 19663693
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105726 (version 83.38)
Entrez gene	57130
UniProt	Q9HD20 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HD20
Antibodypedia	ATP13A1 antibodies

PROTEIN BROWSER

ATP13A1-001	ATP13A1-003	ATP13A1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP13A1-001 ENSP00000349877 ENST00000357324	Q9HD20 [Direct mapping] Manganese-transporting ATPase 13A1 A0A024R7N2 [Target identity:100%; Query identity:100%] ATPase type 13A1, isoform CRA_c Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003674 [molecular_function] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019829 [cation-transporting ATPase activity] GO:0034220 [ion transmembrane transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1204 aa 133 kDa	No	>9
ATP13A1-003 ENSP00000291503 ENST00000291503	Q9HD20 [Direct mapping] Manganese-transporting ATPase 13A1 A0A024R7P3 [Target identity:100%; Query identity:100%] ATPase type 13A1, isoform CRA_f Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003674 [molecular_function] GO:0005524 [ATP binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006812 [cation transport] GO:0006874 [cellular calcium ion homeostasis] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0019829 [cation-transporting ATPase activity] GO:0034220 [ion transmembrane transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] GO:0098655 [cation transmembrane transport] Show all	1086 aa 121.1 kDa	No	>9
ATP13A1-009 ENSP00000411891 ENST00000455627	H7C3H2 [Direct mapping] Manganese-transporting ATPase 13A1 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006812 [cation transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] Show all	185 aa 20.6 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.