Expression of TWISTNB in cancer - Summary

GENERAL INFORMATION
Gene name	TWISTNB
Gene description	TWIST neighbor
Protein class	Predicted intracellular proteins RNA polymerase related proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression combined with nucleolar expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA019071 , HPA022416
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA019071	HPA022416

GENE INFORMATION
Gene name	TWISTNB
Synonyms
Description	TWIST neighbor (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p21.1
Chromosome location (bp)	19695462 - 19709087
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105849 (version 83.38)
Entrez gene	221830
UniProt	Q3B726 (UniProt - Evidence at protein level)
neXtProt	NX_Q3B726
Antibodypedia	TWISTNB antibodies

PROTEIN BROWSER

TWISTNB-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TWISTNB-001 ENSP00000222567 ENST00000222567	Q3B726 [Direct mapping] DNA-directed RNA polymerase I subunit RPA43 Show all	Predicted intracellular proteins RNA polymerase related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001054 [RNA polymerase I activity] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005736 [DNA-directed RNA polymerase I complex] GO:0006351 [transcription, DNA-templated] GO:0006360 [transcription from RNA polymerase I promoter] GO:0006361 [transcription initiation from RNA polymerase I promoter] GO:0006362 [transcription elongation from RNA polymerase I promoter] GO:0006363 [termination of RNA polymerase I transcription] GO:0010467 [gene expression] GO:0015630 [microtubule cytoskeleton] GO:0040029 [regulation of gene expression, epigenetic] GO:0045814 [negative regulation of gene expression, epigenetic] Show all	338 aa 37.4 kDa	No	0