Expression of ADAP1 in cancer - Summary - The Human Protein Atlas

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ADAP1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAP1
Gene description	ArfGAP with dual PH domains 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A-431, CAPAN-2, HMC-1, THP-1)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA007033 , HPA012049
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), colorectal cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007033	HPA012049

GENE INFORMATION
Gene name	ADAP1 (HGNC Symbol)
Synonyms	CENTA1, GCS1L
Description	ArfGAP with dual PH domains 1 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p22.3
Chromosome location (bp)	897901 - 955407
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105963 (version 83.38)
Entrez gene	11033
UniProt	O75689 (UniProt - Evidence at protein level)
neXtProt	NX_O75689
Antibodypedia	ADAP1 antibodies

PROTEIN BROWSER

ADAP1-001	ADAP1-002	ADAP1-005	ADAP1-008	ADAP1-009	ADAP1-012	ADAP1-014	ADAP1-201	ADAP1-202	ADAP1-203	ADAP1-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAP1-001 ENSP00000265846 ENST00000265846	O75689 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	Phobius predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0043087 [regulation of GTPase activity] GO:0043533 [inositol 1,3,4,5 tetrakisphosphate binding] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	374 aa 43.4 kDa	No	0
ADAP1-002 ENSP00000414436 ENST00000446141	H0Y7Q1 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		357 aa 41 kDa	No	0
ADAP1-005 ENSP00000394973 ENST00000435943	C9JN36 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0043547 [positive regulation of GTPase activity] Show all	162 aa 18.8 kDa	No	0
ADAP1-008 ENSP00000391315 ENST00000454383	H7BZT6 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		192 aa 22.4 kDa	No	0
ADAP1-009 ENSP00000416545 ENST00000453823	H7C4B3 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		187 aa 21.8 kDa	No	0
ADAP1-012 ENSP00000404217 ENST00000437486	H7C264 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		207 aa 23.6 kDa	No	0
ADAP1-014 ENSP00000409129 ENST00000453175	H7C324 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	245 aa 28.5 kDa	No	0
ADAP1-201 ENSP00000407267 ENST00000449296	O75689 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0043087 [regulation of GTPase activity] GO:0043533 [inositol 1,3,4,5 tetrakisphosphate binding] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	302 aa 35.4 kDa	No	0
ADAP1-202 ENSP00000442682 ENST00000539900	O75689 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0043087 [regulation of GTPase activity] GO:0043533 [inositol 1,3,4,5 tetrakisphosphate binding] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	385 aa 44.9 kDa	No	0
ADAP1-203 ENSP00000481154 ENST00000611167	O75689 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0043087 [regulation of GTPase activity] GO:0043533 [inositol 1,3,4,5 tetrakisphosphate binding] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	302 aa 35.4 kDa	No	0
ADAP1-204 ENSP00000478011 ENST00000617043	A0A087WTN6 [Direct mapping] Arf-GAP with dual PH domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		279 aa 32.7 kDa	No	0

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