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H2AFV

GENERAL INFORMATION

Gene name

 H2AFV

Gene description

 H2A histone family, member V

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA057236
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and renal cancer (favourable).
Cervical cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057236

GENE INFORMATION

Gene name

 H2AFV (HGNC Symbol)

Synonyms

 H2AV, MGC10170, MGC10831, MGC1947

Description

 H2A histone family, member V (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015]

Chromosome

 7

Cytoband

 p13

Chromosome location (bp)

 44826791 - 44848083

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105968 (version 83.38)

Entrez gene

 94239

UniProt

 Q71UI9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q71UI9

Antibodypedia

 H2AFV antibodies

PROTEIN BROWSER
H2AFV-001
H2AFV-002
H2AFV-003
H2AFV-004
H2AFV-005
H2AFV-006
H2AFV-007
H2AFV-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
H2AFV-001
ENSP00000222690
ENST00000222690
Q71UI9 [Direct mapping]
Histone H2A.V
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0003674 [molecular_function]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006342 [chromatin silencing]
GO:0008150 [biological_process]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
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 114 aa
12.1 kDa 		No 0
H2AFV-002
ENSP00000308405
ENST00000308153
Q71UI9 [Direct mapping]
Histone H2A.V
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0003674 [molecular_function]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006342 [chromatin silencing]
GO:0008150 [biological_process]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
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 128 aa
13.5 kDa 		No 0
H2AFV-003
ENSP00000340708
ENST00000350771
Q71UI9 [Direct mapping]
Histone H2A.V
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0003674 [molecular_function]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006342 [chromatin silencing]
GO:0008150 [biological_process]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
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 102 aa
11 kDa 		No 0
H2AFV-004
ENSP00000342714
ENST00000349299
Q71UI9 [Direct mapping]
Histone H2A.V
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Predicted intracellular proteins
Show all
GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0003674 [molecular_function]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006342 [chromatin silencing]
GO:0008150 [biological_process]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
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 90 aa
9.4 kDa 		No 0
H2AFV-005
ENSP00000397115
ENST00000437072
C9J386 [Direct mapping]
Histone H2A
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Predicted intracellular proteins
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GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0046982 [protein heterodimerization activity]
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 76 aa
8 kDa 		No 0
H2AFV-006
ENSP00000406901
ENST00000446531
C9J0D1 [Direct mapping]
Histone H2A
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0046982 [protein heterodimerization activity]
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 122 aa
13.2 kDa 		No 0
H2AFV-007
ENSP00000370516
ENST00000381124
Q71UI9 [Direct mapping]
Histone H2A.V
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0003674 [molecular_function]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006325 [chromatin organization]
GO:0006342 [chromatin silencing]
GO:0008150 [biological_process]
GO:0046982 [protein heterodimerization activity]
GO:0070062 [extracellular exosome]
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 66 aa
6.9 kDa 		No 0
H2AFV-008
ENSP00000430492
ENST00000521529
E5RJU1 [Direct mapping]
Histone H2A.V
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   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0046982 [protein heterodimerization activity]
Show all
 40 aa
4.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.