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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MET

Gene description

MET proto-oncogene, receptor tyrosine kinase

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression of varying levels in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 2 antibodies.
CAB005282 , CAB018577
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in pancreatic cancer (unfavourable) and head and neck cancer (unfavourable).
Pancreatic cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Renal cancer

STAINING SUMMARY

CAB005282
CAB018577

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues displayed moderate to strong cytoplasmic immunoreactivity. Strongest staining was observed in colorectal cancers.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic staining often combined with case of nuclear positivity was observed in most cancer tissues. Several cervical, lung, renal and skin cancers were weakly stained.

GENE INFORMATION

Gene name

MET (HGNC Symbol)

Synonyms

DFNB97, HGFR, RCCP2

Description

MET proto-oncogene, receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q31.2

Chromosome location (bp)

116672390 - 116798386

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105976 (version 83.38)

Entrez gene

4233

UniProt

P08581 (UniProt - Evidence at protein level)

neXtProt

NX_P08581

Antibodypedia

MET antibodies

PROTEIN BROWSER

MET-001
MET-002
MET-004
MET-005
MET-007
MET-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MET-001
ENSP00000317272
ENST00000318493
P08581 [Direct mapping]
Hepatocyte growth factor receptor
A0A024R728 [Target identity:100%; Query identity:100%]
Receptor protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001886 [endothelial cell morphogenesis]
GO:0001889 [liver development]
GO:0001890 [placenta development]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005008 [hepatocyte growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0008283 [cell proliferation]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010507 [negative regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010828 [positive regulation of glucose transport]
GO:0014812 [muscle cell migration]
GO:0014902 [myotube differentiation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019903 [protein phosphatase binding]
GO:0030534 [adult behavior]
GO:0042593 [glucose homeostasis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0050918 [positive chemotaxis]
GO:0051450 [myoblast proliferation]
GO:0055013 [cardiac muscle cell development]
GO:0060048 [cardiac muscle contraction]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072593 [reactive oxygen species metabolic process]
GO:1900407 [regulation of cellular response to oxidative stress]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
1408 aa
157.7 kDa
Yes 1
MET-002
ENSP00000380860
ENST00000397752
P08581 [Direct mapping]
Hepatocyte growth factor receptor
A0A024R759 [Target identity:100%; Query identity:100%]
Receptor protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001886 [endothelial cell morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005008 [hepatocyte growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010507 [negative regulation of autophagy]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019903 [protein phosphatase binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0050918 [positive chemotaxis]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
1390 aa
155.5 kDa
Yes 1
MET-004
ENSP00000398776
ENST00000422097
H7C174 [Direct mapping]
Hepatocyte growth factor receptor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
214 aa
23.7 kDa
No 0
MET-005
ENSP00000413857
ENST00000456159
C9JKM5 [Direct mapping]
Hepatocyte growth factor receptor
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0017154 [semaphorin receptor activity]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
190 aa
21.3 kDa
Yes 0
MET-007
ENSP00000398140
ENST00000454623
H7C130 [Direct mapping]
Hepatocyte growth factor receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
158 aa
17.2 kDa
No 1
MET-201
ENSP00000410980
ENST00000436117
P08581 [Direct mapping]
Hepatocyte growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001886 [endothelial cell morphogenesis]
GO:0004713 [protein tyrosine kinase activity]
GO:0005008 [hepatocyte growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010507 [negative regulation of autophagy]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019903 [protein phosphatase binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0050918 [positive chemotaxis]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
764 aa
85.7 kDa
Yes 0

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