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Gene name

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Reliability

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Method

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Cancer

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Detectable

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Detectable

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MET
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MET

Gene description

MET proto-oncogene, receptor tyrosine kinase

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression of varying levels in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 2 antibodies.
CAB005282 , CAB018577
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

MET (HGNC Symbol)

Synonyms

DFNB97, HGFR, RCCP2

Description

MET proto-oncogene, receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q31.2

Chromosome location (bp)

116672390 - 116798386

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105976 (version 83.38)

Entrez gene

4233

UniProt

P08581 (UniProt - Evidence at protein level)

neXtProt

NX_P08581

Antibodypedia

MET antibodies

PROTEIN BROWSER

MET-001
MET-002
MET-004
MET-005
MET-007
MET-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MET-001
ENSP00000317272
ENST00000318493
P08581 [Direct mapping]
Hepatocyte growth factor receptor
A0A024R728 [Target identity:100%; Query identity:100%]
Receptor protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001886 [endothelial cell morphogenesis]
GO:0001889 [liver development]
GO:0001890 [placenta development]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005008 [hepatocyte growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0007517 [muscle organ development]
GO:0007519 [skeletal muscle tissue development]
GO:0008283 [cell proliferation]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010507 [negative regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010828 [positive regulation of glucose transport]
GO:0014812 [muscle cell migration]
GO:0014902 [myotube differentiation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019903 [protein phosphatase binding]
GO:0030534 [adult behavior]
GO:0042593 [glucose homeostasis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0050918 [positive chemotaxis]
GO:0051450 [myoblast proliferation]
GO:0055013 [cardiac muscle cell development]
GO:0060048 [cardiac muscle contraction]
GO:0060665 [regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072593 [reactive oxygen species metabolic process]
GO:1900407 [regulation of cellular response to oxidative stress]
GO:1900745 [positive regulation of p38MAPK cascade]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
1408 aa
157.7 kDa
Yes 1
MET-002
ENSP00000380860
ENST00000397752
P08581 [Direct mapping]
Hepatocyte growth factor receptor
A0A024R759 [Target identity:100%; Query identity:100%]
Receptor protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001886 [endothelial cell morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005008 [hepatocyte growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010507 [negative regulation of autophagy]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019903 [protein phosphatase binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0050918 [positive chemotaxis]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
1390 aa
155.5 kDa
Yes 1
MET-004
ENSP00000398776
ENST00000422097
H7C174 [Direct mapping]
Hepatocyte growth factor receptor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
214 aa
23.7 kDa
No 0
MET-005
ENSP00000413857
ENST00000456159
C9JKM5 [Direct mapping]
Hepatocyte growth factor receptor
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0017154 [semaphorin receptor activity]
GO:0071526 [semaphorin-plexin signaling pathway]
Show all
190 aa
21.3 kDa
Yes 0
MET-007
ENSP00000398140
ENST00000454623
H7C130 [Direct mapping]
Hepatocyte growth factor receptor
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
158 aa
17.2 kDa
No 1
MET-201
ENSP00000410980
ENST00000436117
P08581 [Direct mapping]
Hepatocyte growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001886 [endothelial cell morphogenesis]
GO:0004713 [protein tyrosine kinase activity]
GO:0005008 [hepatocyte growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007411 [axon guidance]
GO:0008283 [cell proliferation]
GO:0009925 [basal plasma membrane]
GO:0009986 [cell surface]
GO:0010507 [negative regulation of autophagy]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019903 [protein phosphatase binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048012 [hepatocyte growth factor receptor signaling pathway]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0050918 [positive chemotaxis]
GO:0071526 [semaphorin-plexin signaling pathway]
GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
764 aa
85.7 kDa
Yes 0

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