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ABHD11

GENERAL INFORMATION

Gene name

 ABHD11

Gene description

 Abhydrolase domain containing 11

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA024042 , HPA049641
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Thyroid cancer

STAINING SUMMARY
HPA024042
HPA049641

GENE INFORMATION

Gene name

 ABHD11 (HGNC Symbol)

Synonyms

 PP1226, WBSCR21

Description

 Abhydrolase domain containing 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing an alpha/beta hydrolase fold domain. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 73736094 - 73738867

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106077 (version 83.38)

Entrez gene

 83451

UniProt

 Q8NFV4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFV4

Antibodypedia

 ABHD11 antibodies

PROTEIN BROWSER
ABHD11-001
ABHD11-003
ABHD11-007
ABHD11-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABHD11-001
ENSP00000222800
ENST00000222800
Q8NFV4 [Direct mapping]
Alpha/beta hydrolase domain-containing protein 11
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0005575 [cellular_component]
GO:0005739 [mitochondrion]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
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 315 aa
34.7 kDa 		No 0
ABHD11-003
ENSP00000416970
ENST00000437775
Q8NFV4 [Direct mapping]
Alpha/beta hydrolase domain-containing protein 11
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005575 [cellular_component]
GO:0005739 [mitochondrion]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
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 308 aa
33.9 kDa 		No 0
ABHD11-007
ENSP00000378579
ENST00000395147
Q8NFV4 [Direct mapping]
Alpha/beta hydrolase domain-containing protein 11
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005575 [cellular_component]
GO:0005739 [mitochondrion]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
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 258 aa
28.5 kDa 		No 0
ABHD11-009
ENSP00000397666
ENST00000458339
C9J7Q4 [Direct mapping]
Alpha/beta hydrolase domain-containing protein 11
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 159 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.