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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CASP2
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CASP2

Gene description

Caspase 2, apoptosis-related cysteine peptidase

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA050678 , CAB012175
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), ovarian cancer (favourable) and cervical cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Ovarian cancer p<0.001
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA050678
CAB012175

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate to strong cytoplasmic and/or membranous staining with additional nuclear positivity in few cases. Several cases of gliomas, lymphomas, testicular and renal cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most tumour tissues showed weak to moderate cytoplasmic positivity occasionally combined with nuclear staining.

GENE INFORMATION

Gene name

CASP2 (HGNC Symbol)

Synonyms

ICH1, MGC2181, NEDD2, PPP1R57

Description

Caspase 2, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Chromosome

7

Cytoband

q34

Chromosome location (bp)

143288215 - 143307696

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106144 (version 83.38)

Entrez gene

835

UniProt

P42575 (UniProt - Evidence at protein level)

neXtProt

NX_P42575

Antibodypedia

CASP2 antibodies

PROTEIN BROWSER

CASP2-001
CASP2-005
CASP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP2-001
ENSP00000312664
ENST00000310447
P42575 [Direct mapping]
Caspase-2 Caspase-2 subunit p18 Caspase-2 subunit p13 Caspase-2 subunit p12
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001554 [luteolysis]
GO:0003407 [neural retina development]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007420 [brain development]
GO:0007568 [aging]
GO:0008234 [cysteine-type peptidase activity]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0016020 [membrane]
GO:0016485 [protein processing]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0035234 [ectopic germ cell programmed cell death]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043281 [regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0071260 [cellular response to mechanical stimulus]
GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process]
GO:0097190 [apoptotic signaling pathway]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097194 [execution phase of apoptosis]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
GO:2001235 [positive regulation of apoptotic signaling pathway]
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452 aa
50.7 kDa
No 0
CASP2-005
ENSP00000376656
ENST00000392925
C9JRR9 [Direct mapping]
Caspase-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0042981 [regulation of apoptotic process]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
171 aa
19.1 kDa
No 0
CASP2-201
ENSP00000481929
ENST00000619992
A0A087WYM1 [Direct mapping]
Caspase-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0042981 [regulation of apoptotic process]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
Show all
108 aa
12.1 kDa
No 0

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