Expression of ZKSCAN1 in cancer - Summary - The Human Protein Atlas

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ZKSCAN1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZKSCAN1
Gene description	Zinc finger with KRAB and SCAN domains 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA006672
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA006672

GENE INFORMATION
Gene name	ZKSCAN1 (HGNC Symbol)
Synonyms	KOX18, PHZ-37, ZNF139, ZNF36, ZSCAN33
Description	Zinc finger with KRAB and SCAN domains 1 (HGNC Symbol)
Entrez gene summary	The ZKSCAN1 gene encodes a transcriptional regulator of the KRAB (Kruppel-associated box) subfamily of zinc finger proteins, which contain repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links (summarized by Tommerup and Vissing, 1995 [PubMed 7557990]). Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. See ZNF91 (MIM 603971) for general information on zinc finger proteins.[supplied by OMIM, Jul 2010]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100015572 - 100041689
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106261 (version 83.38)
Entrez gene	7586
UniProt	P17029 (UniProt - Evidence at protein level)
neXtProt	NX_P17029
Antibodypedia	ZKSCAN1 antibodies

PROTEIN BROWSER

ZKSCAN1-001	ZKSCAN1-003	ZKSCAN1-004	ZKSCAN1-201	ZKSCAN1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZKSCAN1-001 ENSP00000323148 ENST00000324306	P17029 [Direct mapping] Zinc finger protein with KRAB and SCAN domains 1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	563 aa 63.6 kDa	No	0
ZKSCAN1-003 ENSP00000409172 ENST00000426572	E9PC66 [Direct mapping] Zinc finger protein with KRAB and SCAN domains 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	527 aa 59.7 kDa	No	0
ZKSCAN1-004 ENSP00000394445 ENST00000432317	C9JRM9 [Direct mapping] Zinc finger protein with KRAB and SCAN domains 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated] Show all	125 aa 14.7 kDa	No	0
ZKSCAN1-201 ENSP00000443508 ENST00000535170	B3KRF7 [Direct mapping] Zinc finger protein with KRAB and SCAN domains 1; cDNA FLJ34152 fis, clone FCBBF3012901, highly similar to Zinc finger with KRAB and SCAN domain-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	350 aa 39.3 kDa	No	0
ZKSCAN1-202 ENSP00000480305 ENST00000620510	E9PC66 [Direct mapping] Zinc finger protein with KRAB and SCAN domains 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] Show all	527 aa 59.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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