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ZKSCAN1

GENERAL INFORMATION

Gene name

 ZKSCAN1

Gene description

 Zinc finger with KRAB and SCAN domains 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA006672
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ZKSCAN1 (HGNC Symbol)

Synonyms

 KOX18, PHZ-37, ZNF139, ZNF36, ZSCAN33

Description

 Zinc finger with KRAB and SCAN domains 1 (HGNC Symbol)

Entrez gene summary

 The ZKSCAN1 gene encodes a transcriptional regulator of the KRAB (Kruppel-associated box) subfamily of zinc finger proteins, which contain repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links (summarized by Tommerup and Vissing, 1995 [PubMed 7557990]). Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. See ZNF91 (MIM 603971) for general information on zinc finger proteins.[supplied by OMIM, Jul 2010]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100015572 - 100041689

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106261 (version 83.38)

Entrez gene

 7586

UniProt

 P17029 (UniProt - Evidence at protein level)

neXtProt

 NX_P17029

Antibodypedia

 ZKSCAN1 antibodies

PROTEIN BROWSER
ZKSCAN1-001
ZKSCAN1-003
ZKSCAN1-004
ZKSCAN1-201
ZKSCAN1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZKSCAN1-001
ENSP00000323148
ENST00000324306
P17029 [Direct mapping]
Zinc finger protein with KRAB and SCAN domains 1
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
GO:0046872 [metal ion binding]
Show all
 563 aa
63.6 kDa 		No 0
ZKSCAN1-003
ENSP00000409172
ENST00000426572
E9PC66 [Direct mapping]
Zinc finger protein with KRAB and SCAN domains 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 527 aa
59.7 kDa 		No 0
ZKSCAN1-004
ENSP00000394445
ENST00000432317
C9JRM9 [Direct mapping]
Zinc finger protein with KRAB and SCAN domains 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 125 aa
14.7 kDa 		No 0
ZKSCAN1-201
ENSP00000443508
ENST00000535170
B3KRF7 [Direct mapping]
Zinc finger protein with KRAB and SCAN domains 1; cDNA FLJ34152 fis, clone FCBBF3012901, highly similar to Zinc finger with KRAB and SCAN domain-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 350 aa
39.3 kDa 		No 0
ZKSCAN1-202
ENSP00000480305
ENST00000620510
E9PC66 [Direct mapping]
Zinc finger protein with KRAB and SCAN domains 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
Show all
 527 aa
59.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.