Expression of AIMP2 in cancer - Summary - The Human Protein Atlas

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AIMP2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AIMP2
Gene description	Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA019098 , HPA020057
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), urothelial cancer (unfavourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019098	HPA020057

GENE INFORMATION
Gene name	AIMP2 (HGNC Symbol)
Synonyms	JTV-1, JTV1, p38, PRO0992
Description	Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (HGNC Symbol)
Entrez gene summary	The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p22.1
Chromosome location (bp)	6009245 - 6023834
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106305 (version 83.38)
Entrez gene	7965
UniProt	Q13155 (UniProt - Evidence at protein level)
neXtProt	NX_Q13155
Antibodypedia	AIMP2 antibodies

PROTEIN BROWSER

AIMP2-001	AIMP2-003	AIMP2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AIMP2-001 ENSP00000223029 ENST00000223029	Q13155 [Direct mapping] Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 A0A024QZY1 [Target identity:100%; Query identity:100%] JTV1 gene, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006915 [apoptotic process] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0031398 [positive regulation of protein ubiquitination] GO:0060510 [Type II pneumocyte differentiation] GO:1901216 [positive regulation of neuron death] Show all	320 aa 35.3 kDa	No	0
AIMP2-003 ENSP00000383327 ENST00000400479	A8MU58 [Direct mapping] Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		242 aa 26.8 kDa	No	0
AIMP2-004 ENSP00000378658 ENST00000395236	F8W950 [Direct mapping] Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		251 aa 27.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.