Cell atlas - RBM28 - The Human Protein Atlas

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RBM28

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	RBM28
Gene description	RNA binding motif protein 28
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA026672 , HPA031519
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA026672	A-431	Nucleoli
HPA026672	U-2 OS	Nucleoli
HPA026672	U-251 MG	Nucleoli
HPA031519	A-431	Nucleoli
HPA031519	U-2 OS	Nucleoli
HPA031519	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	RBM28 (HGNC Symbol)
Synonyms	FLJ10377
Description	RNA binding motif protein 28 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	7
Cytoband	q32.1
Chromosome location (bp)	128297685 - 128343908
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106344 (version 83.38)
Entrez gene	55131
UniProt	Q9NW13 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NW13
Antibodypedia	RBM28 antibodies

PROTEIN BROWSER

RBM28-001	RBM28-002	RBM28-003	RBM28-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBM28-001 ENSP00000223073 ENST00000223073	Q9NW13 [Direct mapping] RNA-binding protein 28 A0A024R753 [Target identity:100%; Query identity:100%] RNA binding motif protein 28, isoform CRA_a Show all	Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005681 [spliceosomal complex] GO:0005730 [nucleolus] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0044822 [poly(A) RNA binding] Show all	759 aa 85.7 kDa	No	0
RBM28-002 ENSP00000390517 ENST00000415472	Q9NW13 [Direct mapping] RNA-binding protein 28 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005681 [spliceosomal complex] GO:0005730 [nucleolus] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0044822 [poly(A) RNA binding] Show all	618 aa 69.9 kDa	No	0
RBM28-003 ENSP00000420503 ENST00000459726	C9JE21 [Direct mapping] RNA-binding protein 28 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	204 aa 22.7 kDa	No	0
RBM28-005 ENSP00000418071 ENST00000478061	C9JAA9 [Direct mapping] RNA-binding protein 28 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	283 aa 31.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.