Expression of RBM28 in cancer - Summary

GENERAL INFORMATION
Gene name	RBM28
Gene description	RNA binding motif protein 28
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in the nucleoli of most cell types, highly abundant in neuronal cells and glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA019058 , HPA026672
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (unfavourable) and melanoma (unfavourable).
Liver cancer p<0.001 Endometrial cancer p<0.001 Melanoma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA019058	HPA026672

GENE INFORMATION
Gene name	RBM28 (HGNC Symbol)
Synonyms	FLJ10377
Description	RNA binding motif protein 28 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	7
Cytoband	q32.1
Chromosome location (bp)	128297685 - 128343908
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106344 (version 83.38)
Entrez gene	55131
UniProt	Q9NW13 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NW13
Antibodypedia	RBM28 antibodies

PROTEIN BROWSER

RBM28-001	RBM28-002	RBM28-003	RBM28-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBM28-001 ENSP00000223073 ENST00000223073	Q9NW13 [Direct mapping] RNA-binding protein 28 A0A024R753 [Target identity:100%; Query identity:100%] RNA binding motif protein 28, isoform CRA_a Show all	Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005681 [spliceosomal complex] GO:0005730 [nucleolus] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0044822 [poly(A) RNA binding] Show all	759 aa 85.7 kDa	No	0
RBM28-002 ENSP00000390517 ENST00000415472	Q9NW13 [Direct mapping] RNA-binding protein 28 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0005681 [spliceosomal complex] GO:0005730 [nucleolus] GO:0006397 [mRNA processing] GO:0008380 [RNA splicing] GO:0044822 [poly(A) RNA binding] Show all	618 aa 69.9 kDa	No	0
RBM28-003 ENSP00000420503 ENST00000459726	C9JE21 [Direct mapping] RNA-binding protein 28 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	204 aa 22.7 kDa	No	0
RBM28-005 ENSP00000418071 ENST00000478061	C9JAA9 [Direct mapping] RNA-binding protein 28 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	283 aa 31.8 kDa	No	0