Expression of AGFG2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

AGFG2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AGFG2
Gene description	ArfGAP with FG repeats 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA019689
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019689

GENE INFORMATION
Gene name	AGFG2 (HGNC Symbol)
Synonyms	HRBL, RABR
Description	ArfGAP with FG repeats 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100539211 - 100568219
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106351 (version 83.38)
Entrez gene	3268
UniProt	O95081 (UniProt - Evidence at protein level)
neXtProt	NX_O95081
Antibodypedia	AGFG2 antibodies

PROTEIN BROWSER

AGFG2-001	AGFG2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGFG2-001 ENSP00000300176 ENST00000300176	O95081 [Direct mapping] Arf-GAP domain and FG repeat-containing protein 2 A4D2D6 [Target identity:100%; Query identity:100%] HIV-1 Rev binding protein-like; HIV-1 Rev binding protein-like, isoform CRA_a; cDNA, FLJ95867, highly similar to Homo sapiens HIV-1 Rev binding protein-like (HRBL), mRNA Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005096 [GTPase activator activity] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	481 aa 49 kDa	No	0
AGFG2-005 ENSP00000388594 ENST00000429987	H7BZA5 [Direct mapping] Arf-GAP domain and FG repeat-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		223 aa 21.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.