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AGFG2

GENERAL INFORMATION

Gene name

 AGFG2

Gene description

 ArfGAP with FG repeats 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (salivary gland)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in salivary gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA019689
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (salivary gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AGFG2 (HGNC Symbol)

Synonyms

 HRBL, RABR

Description

 ArfGAP with FG repeats 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Feb 2013]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 100539211 - 100568219

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106351 (version 83.38)

Entrez gene

 3268

UniProt

 O95081 (UniProt - Evidence at protein level)

neXtProt

 NX_O95081

Antibodypedia

 AGFG2 antibodies

PROTEIN BROWSER
AGFG2-001
AGFG2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGFG2-001
ENSP00000300176
ENST00000300176
O95081 [Direct mapping]
Arf-GAP domain and FG repeat-containing protein 2
A4D2D6 [Target identity:100%; Query identity:100%]
HIV-1 Rev binding protein-like; HIV-1 Rev binding protein-like, isoform CRA_a; cDNA, FLJ95867, highly similar to Homo sapiens HIV-1 Rev binding protein-like (HRBL), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0005096 [GTPase activator activity]
GO:0008150 [biological_process]
GO:0016020 [membrane]
GO:0043547 [positive regulation of GTPase activity]
GO:0046872 [metal ion binding]
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 481 aa
49 kDa 		No 0
AGFG2-005
ENSP00000388594
ENST00000429987
H7BZA5 [Direct mapping]
Arf-GAP domain and FG repeat-containing protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 223 aa
21.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.