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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SERPINE1
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SERPINE1

Gene description

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HUVEC TERT2, TIME, U-138 MG, U-251 MG)
HPA (normal tissue):Tissue enhanced (gallbladder, placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in endothelial cells and stromal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Approved based on 1 antibody.
HPA050039
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), stomach cancer (unfavourable), lung cancer (unfavourable), head and neck cancer (unfavourable), colorectal cancer (unfavourable), cervical cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001
Stomach cancer p<0.001
Lung cancer p<0.001
Head and neck cancer p<0.001
Colorectal cancer p<0.001
Cervical cancer p<0.001
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY

HPA050039

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic immunoreactivity was observed in malignant gliomas. Several cases of malignant melanomas, thyroid and colorectal cancers along with a few seminomas, squamous cell carcinomas and pancreatic cancers were moderately stained. Remaining malignant tissues were weakly stained or negative.

GENE INFORMATION

Gene name

SERPINE1 (HGNC Symbol)

Synonyms

PAI, PAI1, PLANH1

Description

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

101127089 - 101139266

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106366 (version 83.38)

Entrez gene

5054

UniProt

P05121 (UniProt - Evidence at protein level)

neXtProt

NX_P05121

Antibodypedia

SERPINE1 antibodies

PROTEIN BROWSER

SERPINE1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SERPINE1-001
ENSP00000223095
ENST00000223095
P05121 [Direct mapping]
Plasminogen activator inhibitor 1
A0A024QYT5 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 1, isoform CRA_b
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   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001300 [chronological cell aging]
GO:0001525 [angiogenesis]
GO:0001890 [placenta development]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0007623 [circadian rhythm]
GO:0010467 [gene expression]
GO:0010469 [regulation of receptor activity]
GO:0010757 [negative regulation of plasminogen activation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0030168 [platelet activation]
GO:0030194 [positive regulation of blood coagulation]
GO:0030195 [negative regulation of blood coagulation]
GO:0030198 [extracellular matrix organization]
GO:0030336 [negative regulation of cell migration]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0035491 [positive regulation of leukotriene production involved in inflammatory response]
GO:0042127 [regulation of cell proliferation]
GO:0042730 [fibrinolysis]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0051918 [negative regulation of fibrinolysis]
GO:0061044 [negative regulation of vascular wound healing]
GO:0061045 [negative regulation of wound healing]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2000098 [negative regulation of smooth muscle cell-matrix adhesion]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
402 aa
45.1 kDa
Yes 0

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