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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

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Searches

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Cancer

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Detectable

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Detectable

Cancer

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SERPINE1
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

SERPINE1

Gene description

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (gallbladder, placenta)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Distinct expression in endothelial cells and stromal cells.

DATA RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.

Reliability score

Approved based on 1 antibody.
HPA050039
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

SERPINE1 (HGNC Symbol)

Synonyms

PAI, PAI1, PLANH1

Description

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

7

Cytoband

q22.1

Chromosome location (bp)

101127089 - 101139266

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106366 (version 83.38)

Entrez gene

5054

UniProt

P05121 (UniProt - Evidence at protein level)

neXtProt

NX_P05121

Antibodypedia

SERPINE1 antibodies

PROTEIN BROWSER

SERPINE1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SERPINE1-001
ENSP00000223095
ENST00000223095
P05121 [Direct mapping]
Plasminogen activator inhibitor 1
A0A024QYT5 [Target identity:100%; Query identity:100%]
Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 1, isoform CRA_b
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   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001300 [chronological cell aging]
GO:0001525 [angiogenesis]
GO:0001890 [placenta development]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0007623 [circadian rhythm]
GO:0010467 [gene expression]
GO:0010469 [regulation of receptor activity]
GO:0010757 [negative regulation of plasminogen activation]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0030168 [platelet activation]
GO:0030194 [positive regulation of blood coagulation]
GO:0030195 [negative regulation of blood coagulation]
GO:0030198 [extracellular matrix organization]
GO:0030336 [negative regulation of cell migration]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0033629 [negative regulation of cell adhesion mediated by integrin]
GO:0035491 [positive regulation of leukotriene production involved in inflammatory response]
GO:0042127 [regulation of cell proliferation]
GO:0042730 [fibrinolysis]
GO:0045765 [regulation of angiogenesis]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0050729 [positive regulation of inflammatory response]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0051918 [negative regulation of fibrinolysis]
GO:0061044 [negative regulation of vascular wound healing]
GO:0061045 [negative regulation of wound healing]
GO:0070062 [extracellular exosome]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:2000098 [negative regulation of smooth muscle cell-matrix adhesion]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
402 aa
45.1 kDa
Yes 0

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