Expression of GLCCI1 in cancer - Summary - The Human Protein Atlas

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GLCCI1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GLCCI1
Gene description	Glucocorticoid induced 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-266/70)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA001674 , HPA005987
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001674	HPA005987

GENE INFORMATION
Gene name	GLCCI1 (HGNC Symbol)
Synonyms	FAM117C, GIG18, TSSN1
Description	Glucocorticoid induced 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012]
Chromosome	7
Cytoband	p21.3
Chromosome location (bp)	7968794 - 8094272
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106415 (version 83.38)
Entrez gene	113263
UniProt	Q86VQ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q86VQ1
Antibodypedia	GLCCI1 antibodies

PROTEIN BROWSER

GLCCI1-001	GLCCI1-008	GLCCI1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLCCI1-001 ENSP00000223145 ENST00000223145	Q86VQ1 [Direct mapping] Glucocorticoid-induced transcript 1 protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	547 aa 58 kDa	No	0
GLCCI1-008 ENSP00000406569 ENST00000414914	H7C2L5 [Direct mapping] Glucocorticoid-induced transcript 1 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		192 aa 21.2 kDa	No	0
GLCCI1-009 ENSP00000396171 ENST00000430798	H7C0Q2 [Direct mapping] Glucocorticoid-induced transcript 1 protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	194 aa 21.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.