Fields »
ABOUT
HELP
BLOG
AEBP1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 AEBP1

Gene description

 AE binding protein 1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to vesicles. In addition localized to the cytosol & nucleoplasm.

RNA cell category

 Cell line enhanced (BJ, WM-115, BJ hTERT+)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported)

Additional location

 In addition localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
CAB009966 , HPA047724
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ, WM-115, BJ hTERT+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to vesicles. In addition localized to the cytosol & nucleoplasm.

Main location

 Vesicles (supported)

Additional location

 Nucleoplasm (approved), Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA047724 BJ Nucleoplasm
Vesicles
HPA047724 MCF7 Nucleoplasm
Vesicles
HPA047724 U-2 OS Vesicles
CAB009966 MCF7 Vesicles
CAB009966 U-2 OS Vesicles
Cytosol

GENE INFORMATION

Gene name

 AEBP1 (HGNC Symbol)

Synonyms

 ACLP

Description

 AE binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]

Chromosome

 7

Cytoband

 p13

Chromosome location (bp)

 44104361 - 44114562

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106624 (version 83.38)

Entrez gene

 165

UniProt

 Q8IUX7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IUX7

Antibodypedia

 AEBP1 antibodies

PROTEIN BROWSER
AEBP1-001
AEBP1-002
AEBP1-004
AEBP1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AEBP1-001
ENSP00000223357
ENST00000223357
Q8IUX7 [Direct mapping]
Adipocyte enhancer-binding protein 1
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001501 [skeletal system development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0005516 [calmodulin binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006508 [proteolysis]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
GO:0070062 [extracellular exosome]
Show all
 1158 aa
130.9 kDa 		Yes 0
AEBP1-002
ENSP00000398878
ENST00000450684
Q8IUX7 [Direct mapping]
Adipocyte enhancer-binding protein 1
Show all
Enzymes
   Peptidases
   Metallopeptidases
   SCAMPI predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001501 [skeletal system development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004180 [carboxypeptidase activity]
GO:0004181 [metallocarboxypeptidase activity]
GO:0005516 [calmodulin binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006508 [proteolysis]
GO:0007517 [muscle organ development]
GO:0008270 [zinc ion binding]
GO:0031012 [extracellular matrix]
GO:0070062 [extracellular exosome]
Show all
 733 aa
82.2 kDa 		No 0
AEBP1-004
ENSP00000411277
ENST00000455443
H7C3D7 [Direct mapping]
Adipocyte enhancer-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 251 aa
27.6 kDa 		No 0
AEBP1-005
ENSP00000401758
ENST00000449162
C9JLQ8 [Direct mapping]
Adipocyte enhancer-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 162 aa
18.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.