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MYL7

GENERAL INFORMATION

Gene name

 MYL7

Gene description

 Myosin, light chain 7, regulatory

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Group enriched (BEWO, CACO-2)
HPA (normal tissue):Tissue enriched (heart muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in heart muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA013331 , HPA039262 , CAB033884
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA013331
HPA039262
CAB033884

GENE INFORMATION

Gene name

 MYL7 (HGNC Symbol)

Synonyms

 MYL2A, MYLC2A

Description

 Myosin, light chain 7, regulatory (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 p13

Chromosome location (bp)

 44138864 - 44141332

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106631 (version 83.38)

Entrez gene

 58498

UniProt

 Q01449 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01449

Antibodypedia

 MYL7 antibodies

PROTEIN BROWSER
MYL7-001
MYL7-003
MYL7-004
MYL7-005
MYL7-006
MYL7-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYL7-001
ENSP00000223364
ENST00000223364
Q01449 [Direct mapping]
Myosin regulatory light chain 2, atrial isoform
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006936 [muscle contraction]
GO:0016459 [myosin complex]
GO:0031672 [A band]
GO:0043197 [dendritic spine]
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 175 aa
19.4 kDa 		No 0
MYL7-003
ENSP00000403360
ENST00000458240
C9JEG4 [Direct mapping]
Myosin regulatory light chain 2, atrial isoform; Myosin, light polypeptide 7, regulatory
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 148 aa
16.7 kDa 		No 0
MYL7-004
ENSP00000411340
ENST00000431007
H7C3E3 [Direct mapping]
Myosin regulatory light chain 2, atrial isoform
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 108 aa
11.7 kDa 		No 0
MYL7-005
ENSP00000389202
ENST00000457314
H7BZE4 [Direct mapping]
Myosin regulatory light chain 2, atrial isoform
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 197 aa
21.7 kDa 		No 0
MYL7-006
ENSP00000403988
ENST00000447951
H7C243 [Direct mapping]
Myosin regulatory light chain 2, atrial isoform
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 172 aa
18.5 kDa 		No 0
MYL7-010
ENSP00000416010
ENST00000446581
H7C482 [Direct mapping]
Myosin regulatory light chain 2, atrial isoform
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 135 aa
15 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.