Tissue expression of MYL7 - Summary - The Human Protein Atlas

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MYL7

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MYL7
Gene description	Myosin, light chain 7, regulatory
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (heart muscle)
GTEx:	Tissue enriched (heart muscle)
FANTOM5:	Tissue enriched (heart muscle)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in heart muscle.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA013331 , HPA039262 , CAB033884
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (heart muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (heart muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (heart muscle)

GENE INFORMATION
Gene name	MYL7 (HGNC Symbol)
Synonyms	MYL2A, MYLC2A
Description	Myosin, light chain 7, regulatory (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p13
Chromosome location (bp)	44138864 - 44141332
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106631 (version 83.38)
Entrez gene	58498
UniProt	Q01449 (UniProt - Evidence at protein level)
neXtProt	NX_Q01449
Antibodypedia	MYL7 antibodies

PROTEIN BROWSER

MYL7-001	MYL7-003	MYL7-004	MYL7-005	MYL7-006	MYL7-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYL7-001 ENSP00000223364 ENST00000223364	Q01449 [Direct mapping] Myosin regulatory light chain 2, atrial isoform Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006936 [muscle contraction] GO:0016459 [myosin complex] GO:0031672 [A band] GO:0043197 [dendritic spine] Show all	175 aa 19.4 kDa	No	0
MYL7-003 ENSP00000403360 ENST00000458240	C9JEG4 [Direct mapping] Myosin regulatory light chain 2, atrial isoform; Myosin, light polypeptide 7, regulatory Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	148 aa 16.7 kDa	No	0
MYL7-004 ENSP00000411340 ENST00000431007	H7C3E3 [Direct mapping] Myosin regulatory light chain 2, atrial isoform Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	108 aa 11.7 kDa	No	0
MYL7-005 ENSP00000389202 ENST00000457314	H7BZE4 [Direct mapping] Myosin regulatory light chain 2, atrial isoform Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	197 aa 21.7 kDa	No	0
MYL7-006 ENSP00000403988 ENST00000447951	H7C243 [Direct mapping] Myosin regulatory light chain 2, atrial isoform Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	172 aa 18.5 kDa	No	0
MYL7-010 ENSP00000416010 ENST00000446581	H7C482 [Direct mapping] Myosin regulatory light chain 2, atrial isoform Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	135 aa 15 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.