Expression of BCL7B in cancer - Summary - The Human Protein Atlas

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BCL7B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BCL7B
Gene description	B-cell CLL/lymphoma 7B
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA058069
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA058069

GENE INFORMATION
Gene name	BCL7B
Synonyms
Description	B-cell CLL/lymphoma 7B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010]
Chromosome	7
Cytoband	q11.23
Chromosome location (bp)	73536356 - 73558002
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106635 (version 83.38)
Entrez gene	9275
UniProt	Q9BQE9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BQE9
Antibodypedia	BCL7B antibodies

PROTEIN BROWSER

BCL7B-001	BCL7B-002	BCL7B-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL7B-001 ENSP00000223368 ENST00000223368	Q9BQE9 [Direct mapping] B-cell CLL/lymphoma 7 protein family member B Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	202 aa 22.2 kDa	No	0
BCL7B-002 ENSP00000393230 ENST00000411832	Q9BQE9 [Direct mapping] B-cell CLL/lymphoma 7 protein family member B Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	145 aa 16 kDa	No	0
BCL7B-006 ENSP00000411073 ENST00000455335	F2Z3H6 [Direct mapping] B-cell CLL/lymphoma 7 protein family member B; B-cell CLL/lymphoma 7B, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 23.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.