Cell atlas - ASPN - The Human Protein Atlas

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ASPN

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	ASPN
Gene description	Asporin
Protein class	Disease related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus but also to vesicles.
RNA cell category	Cell line enhanced (ASC TERT1, BJ hTERT+, BJ)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Vesicles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA024230
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, BJ) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus but also to vesicles.

Main location

Nucleoplasm (approved), Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024230	ASC TERT1	Nucleoplasm
	HPA024230	ASC TERT1	Vesicles
	HPA024230	U-2 OS	Nucleoplasm
	HPA024230	U-2 OS	Vesicles
	HPA024230	U-251 MG	Nucleoplasm
	HPA024230	U-251 MG	Vesicles

GENE INFORMATION
Gene name	ASPN (HGNC Symbol)
Synonyms	FLJ20129, PLAP1, SLRR1C
Description	Asporin (HGNC Symbol)
Entrez gene summary	This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014]
Chromosome	9
Cytoband	q22.31
Chromosome location (bp)	92456205 - 92482506
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106819 (version 83.38)
Entrez gene	54829
UniProt	Q9BXN1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXN1
Antibodypedia	ASPN antibodies

PROTEIN BROWSER

ASPN-001	ASPN-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASPN-001 ENSP00000364694 ENST00000375544	Q9BXN1 [Direct mapping] Asporin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005578 [proteinaceous extracellular matrix] GO:0030282 [bone mineralization] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031012 [extracellular matrix] GO:0070171 [negative regulation of tooth mineralization] Show all	380 aa 43.4 kDa	Yes	0
ASPN-002 ENSP00000364693 ENST00000375543	Q5TBF2 [Direct mapping] Asporin; Asporin (LRR class 1), isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] Show all	243 aa 27.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.