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ASPN

GENERAL INFORMATION

Gene name

 ASPN

Gene description

 Asporin

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1, BJ, BJ hTERT+)
HPA (normal tissue):Tissue enhanced (endometrium, smooth muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct positivity in extracellular matrix.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 2 antibodies.
HPA008435 , HPA024230
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA008435
HPA024230

GENE INFORMATION

Gene name

 ASPN (HGNC Symbol)

Synonyms

 FLJ20129, PLAP1, SLRR1C

Description

 Asporin (HGNC Symbol)

Entrez gene summary

 This gene encodes a cartilage extracellular protein that is member of the small leucine-rich proteoglycan family. The encoded protein may regulate chondrogenesis by inhibiting transforming growth factor-beta 1-induced gene expression in cartilage. This protein also binds collagen and calcium and may induce collagen mineralization. Polymorphisms in the aspartic acid repeat region of this gene are associated with a susceptibility to osteoarthritis, and also with intervertebral disc disease. Alternative splicing of this gene results in multiple transcript variants.[provided by RefSeq, Jul 2014]

Chromosome

 9

Cytoband

 q22.31

Chromosome location (bp)

 92456205 - 92482506

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106819 (version 83.38)

Entrez gene

 54829

UniProt

 Q9BXN1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BXN1

Antibodypedia

 ASPN antibodies

PROTEIN BROWSER
ASPN-001
ASPN-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASPN-001
ENSP00000364694
ENST00000375544
Q9BXN1 [Direct mapping]
Asporin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0030282 [bone mineralization]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0031012 [extracellular matrix]
GO:0070171 [negative regulation of tooth mineralization]
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 380 aa
43.4 kDa 		Yes 0
ASPN-002
ENSP00000364693
ENST00000375543
Q5TBF2 [Direct mapping]
Asporin; Asporin (LRR class 1), isoform CRA_b
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
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 243 aa
27.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.