Expression of LHX6 in cancer - Summary - The Human Protein Atlas

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LHX6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LHX6
Gene description	LIM homeobox 6
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CACO-2, NB-4, PC-3)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA047854
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047854

GENE INFORMATION
Gene name	LHX6 (HGNC Symbol)
Synonyms	LHX6.1
Description	LIM homeobox 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q33.2
Chromosome location (bp)	122202577 - 122229626
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106852 (version 83.38)
Entrez gene	26468
UniProt	Q9UPM6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPM6
Antibodypedia	LHX6 antibodies

PROTEIN BROWSER

LHX6-001	LHX6-002	LHX6-003	LHX6-004	LHX6-005	LHX6-006	LHX6-008	LHX6-009	LHX6-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LHX6-001 ENSP00000377854 ENST00000394319	Q9UPM6 [Direct mapping] LIM/homeobox protein Lhx6 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0021799 [cerebral cortex radially oriented cell migration] GO:0021800 [cerebral cortex tangential migration] GO:0021853 [cerebral cortex GABAergic interneuron migration] GO:0021877 [forebrain neuron fate commitment] GO:0021884 [forebrain neuron development] GO:0021895 [cerebral cortex neuron differentiation] GO:0043565 [sequence-specific DNA binding] GO:0048469 [cell maturation] Show all	392 aa 43.1 kDa	No	0
LHX6-002 ENSP00000362860 ENST00000373755	Q9UPM6 [Direct mapping] LIM/homeobox protein Lhx6 A0A024R852 [Target identity:100%; Query identity:100%] LIM homeobox 6, isoform CRA_b Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0021799 [cerebral cortex radially oriented cell migration] GO:0021800 [cerebral cortex tangential migration] GO:0021853 [cerebral cortex GABAergic interneuron migration] GO:0043565 [sequence-specific DNA binding] GO:0048469 [cell maturation] Show all	363 aa 40 kDa	No	0
LHX6-003 ENSP00000362859 ENST00000373754	Q9UPM6 [Direct mapping] LIM/homeobox protein Lhx6 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0021799 [cerebral cortex radially oriented cell migration] GO:0021800 [cerebral cortex tangential migration] GO:0021853 [cerebral cortex GABAergic interneuron migration] GO:0043565 [sequence-specific DNA binding] GO:0048469 [cell maturation] Show all	348 aa 38.2 kDa	No	0
LHX6-004 ENSP00000453798 ENST00000482062	H0YMY8 [Direct mapping] LIM/homeobox protein Lhx6 Show all	Predicted intracellular proteins Show all		50 aa 5.6 kDa	No	0
LHX6-005 ENSP00000452811 ENST00000464484	H0YKH7 [Direct mapping] LIM/homeobox protein Lhx6 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		35 aa 3.8 kDa	No	0
LHX6-006 ENSP00000340137 ENST00000340587	Q9UPM6 [Direct mapping] LIM/homeobox protein Lhx6 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0021799 [cerebral cortex radially oriented cell migration] GO:0021800 [cerebral cortex tangential migration] GO:0021853 [cerebral cortex GABAergic interneuron migration] GO:0043565 [sequence-specific DNA binding] GO:0048469 [cell maturation] Show all	377 aa 41.3 kDa	No	0
LHX6-008 ENSP00000475927 ENST00000559895	Q9UPM6 [Direct mapping] LIM/homeobox protein Lhx6 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0021799 [cerebral cortex radially oriented cell migration] GO:0021800 [cerebral cortex tangential migration] GO:0021853 [cerebral cortex GABAergic interneuron migration] GO:0043565 [sequence-specific DNA binding] GO:0048469 [cell maturation] Show all	176 aa 19.6 kDa	No	0
LHX6-009 ENSP00000441464 ENST00000541397	Q9UPM6 [Direct mapping] LIM/homeobox protein Lhx6 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0021799 [cerebral cortex radially oriented cell migration] GO:0021800 [cerebral cortex tangential migration] GO:0021853 [cerebral cortex GABAergic interneuron migration] GO:0043565 [sequence-specific DNA binding] GO:0048469 [cell maturation] Show all	366 aa 40.2 kDa	No	0
LHX6-011 ENSP00000453606 ENST00000560485	H0YMH3 [Direct mapping] LIM/homeobox protein Lhx6 Show all	Predicted intracellular proteins Show all		34 aa 3.3 kDa	No	0

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