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LHX6

GENERAL INFORMATION

Gene name

 LHX6

Gene description

 LIM homeobox 6

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA047854
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 LHX6 (HGNC Symbol)

Synonyms

 LHX6.1

Description

 LIM homeobox 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q33.2

Chromosome location (bp)

 122202577 - 122229626

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106852 (version 83.38)

Entrez gene

 26468

UniProt

 Q9UPM6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPM6

Antibodypedia

 LHX6 antibodies

PROTEIN BROWSER
LHX6-001
LHX6-002
LHX6-003
LHX6-004
LHX6-005
LHX6-006
LHX6-008
LHX6-009
LHX6-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LHX6-001
ENSP00000377854
ENST00000394319
Q9UPM6 [Direct mapping]
LIM/homeobox protein Lhx6
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021800 [cerebral cortex tangential migration]
GO:0021853 [cerebral cortex GABAergic interneuron migration]
GO:0021877 [forebrain neuron fate commitment]
GO:0021884 [forebrain neuron development]
GO:0021895 [cerebral cortex neuron differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0048469 [cell maturation]
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 392 aa
43.1 kDa 		No 0
LHX6-002
ENSP00000362860
ENST00000373755
Q9UPM6 [Direct mapping]
LIM/homeobox protein Lhx6
A0A024R852 [Target identity:100%; Query identity:100%]
LIM homeobox 6, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021800 [cerebral cortex tangential migration]
GO:0021853 [cerebral cortex GABAergic interneuron migration]
GO:0043565 [sequence-specific DNA binding]
GO:0048469 [cell maturation]
Show all
 363 aa
40 kDa 		No 0
LHX6-003
ENSP00000362859
ENST00000373754
Q9UPM6 [Direct mapping]
LIM/homeobox protein Lhx6
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021800 [cerebral cortex tangential migration]
GO:0021853 [cerebral cortex GABAergic interneuron migration]
GO:0043565 [sequence-specific DNA binding]
GO:0048469 [cell maturation]
Show all
 348 aa
38.2 kDa 		No 0
LHX6-004
ENSP00000453798
ENST00000482062
H0YMY8 [Direct mapping]
LIM/homeobox protein Lhx6
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Predicted intracellular proteins
Show all
 50 aa
5.6 kDa 		No 0
LHX6-005
ENSP00000452811
ENST00000464484
H0YKH7 [Direct mapping]
LIM/homeobox protein Lhx6
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
 35 aa
3.8 kDa 		No 0
LHX6-006
ENSP00000340137
ENST00000340587
Q9UPM6 [Direct mapping]
LIM/homeobox protein Lhx6
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021800 [cerebral cortex tangential migration]
GO:0021853 [cerebral cortex GABAergic interneuron migration]
GO:0043565 [sequence-specific DNA binding]
GO:0048469 [cell maturation]
Show all
 377 aa
41.3 kDa 		No 0
LHX6-008
ENSP00000475927
ENST00000559895
Q9UPM6 [Direct mapping]
LIM/homeobox protein Lhx6
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021800 [cerebral cortex tangential migration]
GO:0021853 [cerebral cortex GABAergic interneuron migration]
GO:0043565 [sequence-specific DNA binding]
GO:0048469 [cell maturation]
Show all
 176 aa
19.6 kDa 		No 0
LHX6-009
ENSP00000441464
ENST00000541397
Q9UPM6 [Direct mapping]
LIM/homeobox protein Lhx6
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021800 [cerebral cortex tangential migration]
GO:0021853 [cerebral cortex GABAergic interneuron migration]
GO:0043565 [sequence-specific DNA binding]
GO:0048469 [cell maturation]
Show all
 366 aa
40.2 kDa 		No 0
LHX6-011
ENSP00000453606
ENST00000560485
H0YMH3 [Direct mapping]
LIM/homeobox protein Lhx6
Show all
Predicted intracellular proteins
Show all
 34 aa
3.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.