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NCS1

GENERAL INFORMATION

Gene name

 NCS1

Gene description

 Neuronal calcium sensor 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in neuronal cells and peripheral nerves.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA019713 , CAB018587
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), breast cancer (unfavourable), thyroid cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Breast cancer p<0.001
Thyroid cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019713
CAB018587

GENE INFORMATION

Gene name

 NCS1 (HGNC Symbol)

Synonyms

 FREQ, NCS-1

Description

 Neuronal calcium sensor 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 130172578 - 130237304

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107130 (version 83.38)

Entrez gene

 23413

UniProt

 P62166 (UniProt - Evidence at protein level)

neXtProt

 NX_P62166

Antibodypedia

 NCS1 antibodies

PROTEIN BROWSER
NCS1-001
NCS1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCS1-001
ENSP00000361475
ENST00000372398
P62166 [Direct mapping]
Neuronal calcium sensor 1
A0A024R8B2 [Target identity:100%; Query identity:100%]
Frequenin homolog (Drosophila), isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0010975 [regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031045 [dense core granule]
GO:0031410 [cytoplasmic vesicle]
GO:0032580 [Golgi cisterna membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045921 [positive regulation of exocytosis]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
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 190 aa
21.9 kDa 		No 0
NCS1-003
ENSP00000486695
ENST00000630865
P62166 [Direct mapping]
Neuronal calcium sensor 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0010975 [regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0030054 [cell junction]
GO:0032580 [Golgi cisterna membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 172 aa
19.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.