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NCS1

GENERAL INFORMATION

Gene name

 NCS1

Gene description

 Neuronal calcium sensor 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in neuronal cells and peripheral nerves.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA019713 , CAB018587
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NCS1 (HGNC Symbol)

Synonyms

 FREQ, NCS-1

Description

 Neuronal calcium sensor 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 130172578 - 130237304

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107130 (version 83.38)

Entrez gene

 23413

UniProt

 P62166 (UniProt - Evidence at protein level)

neXtProt

 NX_P62166

Antibodypedia

 NCS1 antibodies

PROTEIN BROWSER
NCS1-001
NCS1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCS1-001
ENSP00000361475
ENST00000372398
P62166 [Direct mapping]
Neuronal calcium sensor 1
A0A024R8B2 [Target identity:100%; Query identity:100%]
Frequenin homolog (Drosophila), isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0010975 [regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0019901 [protein kinase binding]
GO:0030054 [cell junction]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0031045 [dense core granule]
GO:0031410 [cytoplasmic vesicle]
GO:0032580 [Golgi cisterna membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0045921 [positive regulation of exocytosis]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
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 190 aa
21.9 kDa 		No 0
NCS1-003
ENSP00000486695
ENST00000630865
P62166 [Direct mapping]
Neuronal calcium sensor 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0010975 [regulation of neuron projection development]
GO:0014069 [postsynaptic density]
GO:0030054 [cell junction]
GO:0032580 [Golgi cisterna membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045211 [postsynaptic membrane]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
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 172 aa
19.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.