Cell atlas - TYRP1 - The Human Protein Atlas

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TYRP1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	TYRP1
Gene description	Tyrosinase-related protein 1
Protein class	Disease related genes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enriched (SK-MEL-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Mouse	Localized to the Nucleus in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA000937
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SK-MEL-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000937	SK-MEL-30	Vesicles

MOUSE CELLS

Main location

Nucleus

Additional location

Plasma membrane

Mouse gene

ENSMUSG00000005994 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA000937	NIH 3T3	Nucleus
	HPA000937	NIH 3T3	Plasma membrane

GENE INFORMATION
Gene name	TYRP1 (HGNC Symbol)
Synonyms	b-PROTEIN, CAS2, CATB, GP75, OCA3, TRP, TYRP
Description	Tyrosinase-related protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
Chromosome	9
Cytoband	p23
Chromosome location (bp)	12685439 - 12710290
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107165 (version 83.38)
Entrez gene	7306
UniProt	P17643 (UniProt - Evidence at protein level)
neXtProt	NX_P17643
Antibodypedia	TYRP1 antibodies

PROTEIN BROWSER

TYRP1-001	TYRP1-002	TYRP1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TYRP1-001 ENSP00000373570 ENST00000388918	P17643 [Direct mapping] 5,6-dihydroxyindole-2-carboxylic acid oxidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0006582 [melanin metabolic process] GO:0008152 [metabolic process] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016716 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen] GO:0030318 [melanocyte differentiation] GO:0030669 [clathrin-coated endocytic vesicle membrane] GO:0032438 [melanosome organization] GO:0033162 [melanosome membrane] GO:0042438 [melanin biosynthetic process] GO:0042470 [melanosome] GO:0042803 [protein homodimerization activity] GO:0043438 [acetoacetic acid metabolic process] GO:0043473 [pigmentation] GO:0046982 [protein heterodimerization activity] GO:0048023 [positive regulation of melanin biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	537 aa 60.7 kDa	Yes	1
TYRP1-002 ENSP00000370528 ENST00000381136	E7EQI3 [Direct mapping] 5,6-dihydroxyindole-2-carboxylic acid oxidase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005507 [copper ion binding] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0016716 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen] GO:0033162 [melanosome membrane] GO:0042438 [melanin biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	247 aa 27.7 kDa	No	1
TYRP1-005 ENSP00000419006 ENST00000473763	C9JZ52 [Direct mapping] 5,6-dihydroxyindole-2-carboxylic acid oxidase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005507 [copper ion binding] GO:0016716 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen] GO:0033162 [melanosome membrane] GO:0042438 [melanin biosynthetic process] GO:0055114 [oxidation-reduction process] Show all	102 aa 11.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.