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TYRP1

GENERAL INFORMATION

Gene name

 TYRP1

Gene description

 Tyrosinase-related protein 1

Protein class

 Disease related genes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (heart muscle, skin)
GTEx:Group enriched (heart muscle, skin)
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in melanocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA000937 , CAB002520
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

 TYRP1 (HGNC Symbol)

Synonyms

 b-PROTEIN, CAS2, CATB, GP75, OCA3, TRP, TYRP

Description

 Tyrosinase-related protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]

Chromosome

 9

Cytoband

 p23

Chromosome location (bp)

 12685439 - 12710290

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107165 (version 83.38)

Entrez gene

 7306

UniProt

 P17643 (UniProt - Evidence at protein level)

neXtProt

 NX_P17643

Antibodypedia

 TYRP1 antibodies

PROTEIN BROWSER
TYRP1-001
TYRP1-002
TYRP1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TYRP1-001
ENSP00000373570
ENST00000388918
P17643 [Direct mapping]
5,6-dihydroxyindole-2-carboxylic acid oxidase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0006582 [melanin metabolic process]
GO:0008152 [metabolic process]
GO:0010008 [endosome membrane]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0016716 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen]
GO:0030318 [melanocyte differentiation]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032438 [melanosome organization]
GO:0033162 [melanosome membrane]
GO:0042438 [melanin biosynthetic process]
GO:0042470 [melanosome]
GO:0042803 [protein homodimerization activity]
GO:0043438 [acetoacetic acid metabolic process]
GO:0043473 [pigmentation]
GO:0046982 [protein heterodimerization activity]
GO:0048023 [positive regulation of melanin biosynthetic process]
GO:0055114 [oxidation-reduction process]
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 537 aa
60.7 kDa 		Yes 1
TYRP1-002
ENSP00000370528
ENST00000381136
E7EQI3 [Direct mapping]
5,6-dihydroxyindole-2-carboxylic acid oxidase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0016716 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen]
GO:0033162 [melanosome membrane]
GO:0042438 [melanin biosynthetic process]
GO:0055114 [oxidation-reduction process]
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 247 aa
27.7 kDa 		No 1
TYRP1-005
ENSP00000419006
ENST00000473763
C9JZ52 [Direct mapping]
5,6-dihydroxyindole-2-carboxylic acid oxidase
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0016716 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen]
GO:0033162 [melanosome membrane]
GO:0042438 [melanin biosynthetic process]
GO:0055114 [oxidation-reduction process]
Show all
 102 aa
11.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.