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DNMBP

GENERAL INFORMATION

Gene name

 DNMBP

Gene description

 Dynamin binding protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a few tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA037878
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and urothelial cancer (favourable).
Endometrial cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA037878

GENE INFORMATION

Gene name

 DNMBP (HGNC Symbol)

Synonyms

 ARHGEF36, KIAA1010, Tuba

Description

 Dynamin binding protein (HGNC Symbol)

Entrez gene summary

 DNMBP belongs to the DBL (MIM 311030) family of guanine nucleotide exchange factors and plays a role in the regulation of cell junctions (Otani et al., 2006 [PubMed 17015620]).[supplied by OMIM, Mar 2008]

Chromosome

 10

Cytoband

 q24.2

Chromosome location (bp)

 99875577 - 100009919

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107554 (version 83.38)

Entrez gene

 23268

UniProt

 Q6XZF7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6XZF7

Antibodypedia

 DNMBP antibodies

PROTEIN BROWSER
DNMBP-001
DNMBP-002
DNMBP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNMBP-001
ENSP00000315659
ENST00000324109
Q6XZF7 [Direct mapping]
Dynamin-binding protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005795 [Golgi stack]
GO:0005856 [cytoskeleton]
GO:0030054 [cell junction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
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 1577 aa
177.3 kDa 		No 0
DNMBP-002
ENSP00000409476
ENST00000422692
Q5SVK9 [Direct mapping]
Dynamin-binding protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 224 aa
25.3 kDa 		No 0
DNMBP-201
ENSP00000443657
ENST00000543621
Q6XZF7 [Direct mapping]
Dynamin-binding protein
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005795 [Golgi stack]
GO:0005856 [cytoskeleton]
GO:0030054 [cell junction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0045202 [synapse]
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 823 aa
93.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.