Expression of UNC5B in cancer - Summary - The Human Protein Atlas

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UNC5B

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	UNC5B
Gene description	Unc-5 netrin receptor B
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (hTCEpi, SH-SY5Y)
HPA (normal tissue):	Tissue enhanced (seminal vesicle)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), ovarian cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Ovarian cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	UNC5B (HGNC Symbol)
Synonyms	p53RDL1, UNC5H2
Description	Unc-5 netrin receptor B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	71212570 - 71302864
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107731 (version 83.38)
Entrez gene	219699
UniProt	Q8IZJ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZJ1
Antibodypedia	UNC5B antibodies

PROTEIN BROWSER

UNC5B-001	UNC5B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UNC5B-001 ENSP00000362288 ENST00000373192	Q8IZJ1 [Direct mapping] Netrin receptor UNC5B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0012501 [programmed cell death] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0043524 [negative regulation of neuron apoptotic process] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] Show all	934 aa 102.4 kDa	Yes	1
UNC5B-002 ENSP00000334329 ENST00000335350	Q8IZJ1 [Direct mapping] Netrin receptor UNC5B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0012501 [programmed cell death] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0033564 [anterior/posterior axon guidance] GO:0043524 [negative regulation of neuron apoptotic process] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] Show all	945 aa 103.6 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.