Tissue expression of UNC5B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	UNC5B
Gene description	Unc-5 netrin receptor B
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (seminal vesicle)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (seminal vesicle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	UNC5B (HGNC Symbol)
Synonyms	p53RDL1, UNC5H2
Description	Unc-5 netrin receptor B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	71212570 - 71302864
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107731 (version 83.38)
Entrez gene	219699
UniProt	Q8IZJ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZJ1
Antibodypedia	UNC5B antibodies

PROTEIN BROWSER

UNC5B-001	UNC5B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UNC5B-001 ENSP00000362288 ENST00000373192	Q8IZJ1 [Direct mapping] Netrin receptor UNC5B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0012501 [programmed cell death] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0043524 [negative regulation of neuron apoptotic process] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] Show all	934 aa 102.4 kDa	Yes	1
UNC5B-002 ENSP00000334329 ENST00000335350	Q8IZJ1 [Direct mapping] Netrin receptor UNC5B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0012501 [programmed cell death] GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling] GO:0016021 [integral component of membrane] GO:0033564 [anterior/posterior axon guidance] GO:0043524 [negative regulation of neuron apoptotic process] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] Show all	945 aa 103.6 kDa	Yes	1