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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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BMPR1A
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

BMPR1A

Gene description

Bone morphogenetic protein receptor, type IA

Protein class

Cancer-related genes
CD markers
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB019398
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable) and glioma (favourable).
Liver cancer p<0.001
Glioma p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB019398

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several colorectal, ovarian, lung and thyroid cancers showed moderate cytoplasmic staining. Remaining cancers were weakly stained or negative.

GENE INFORMATION

Gene name

BMPR1A (HGNC Symbol)

Synonyms

ACVRLK3, ALK3, CD292

Description

Bone morphogenetic protein receptor, type IA (HGNC Symbol)

Entrez gene summary

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q23.2

Chromosome location (bp)

86756650 - 86932838

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107779 (version 83.38)

Entrez gene

657

UniProt

P36894 (UniProt - Evidence at protein level)

neXtProt

NX_P36894

Antibodypedia

BMPR1A antibodies

PROTEIN BROWSER

BMPR1A-001
BMPR1A-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BMPR1A-001
ENSP00000361107
ENST00000372037
P36894 [Direct mapping]
Bone morphogenetic protein receptor type-1A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001701 [in utero embryonic development]
GO:0001707 [mesoderm formation]
GO:0001756 [somitogenesis]
GO:0001880 [Mullerian duct regression]
GO:0001948 [glycoprotein binding]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0002062 [chondrocyte differentiation]
GO:0003007 [heart morphogenesis]
GO:0003272 [endocardial cushion formation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007389 [pattern specification process]
GO:0007398 [ectoderm development]
GO:0007399 [nervous system development]
GO:0007492 [endoderm development]
GO:0007507 [heart development]
GO:0009897 [external side of plasma membrane]
GO:0009950 [dorsal/ventral axis specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0014032 [neural crest cell development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019827 [stem cell population maintenance]
GO:0021983 [pituitary gland development]
GO:0021998 [neural plate mediolateral regionalization]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0030425 [dendrite]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0035137 [hindlimb morphogenesis]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042733 [embryonic digit morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048339 [paraxial mesoderm development]
GO:0048352 [paraxial mesoderm structural organization]
GO:0048368 [lateral mesoderm development]
GO:0048378 [regulation of lateral mesodermal cell fate specification]
GO:0048382 [mesendoderm development]
GO:0048568 [embryonic organ development]
GO:0048589 [developmental growth]
GO:0048598 [embryonic morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050768 [negative regulation of neurogenesis]
GO:0051216 [cartilage development]
GO:0060021 [palate development]
GO:0060391 [positive regulation of SMAD protein import into nucleus]
GO:0060896 [neural plate pattern specification]
GO:0060914 [heart formation]
GO:0071773 [cellular response to BMP stimulus]
GO:1990712 [HFE-transferrin receptor complex]
GO:2000772 [regulation of cellular senescence]
Show all
532 aa
60.2 kDa
Yes 1
BMPR1A-003
ENSP00000483569
ENST00000480152
A0A087X0P8 [Direct mapping]
Bone morphogenetic protein receptor type-1A
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
41 aa
4.7 kDa
No 0

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