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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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BMPR1A
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

BMPR1A

Gene description

Bone morphogenetic protein receptor, type IA

Protein class

Cancer-related genes
CD markers
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB019398
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

BMPR1A (HGNC Symbol)

Synonyms

ACVRLK3, ALK3, CD292

Description

Bone morphogenetic protein receptor, type IA (HGNC Symbol)

Entrez gene summary

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q23.2

Chromosome location (bp)

86756650 - 86932838

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000107779 (version 83.38)

Entrez gene

657

UniProt

P36894 (UniProt - Evidence at protein level)

neXtProt

NX_P36894

Antibodypedia

BMPR1A antibodies

PROTEIN BROWSER

BMPR1A-001
BMPR1A-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BMPR1A-001
ENSP00000361107
ENST00000372037
P36894 [Direct mapping]
Bone morphogenetic protein receptor type-1A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001701 [in utero embryonic development]
GO:0001707 [mesoderm formation]
GO:0001756 [somitogenesis]
GO:0001880 [Mullerian duct regression]
GO:0001948 [glycoprotein binding]
GO:0002053 [positive regulation of mesenchymal cell proliferation]
GO:0002062 [chondrocyte differentiation]
GO:0003007 [heart morphogenesis]
GO:0003272 [endocardial cushion formation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006468 [protein phosphorylation]
GO:0006955 [immune response]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007389 [pattern specification process]
GO:0007398 [ectoderm development]
GO:0007399 [nervous system development]
GO:0007492 [endoderm development]
GO:0007507 [heart development]
GO:0009897 [external side of plasma membrane]
GO:0009950 [dorsal/ventral axis specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0014032 [neural crest cell development]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019827 [stem cell population maintenance]
GO:0021983 [pituitary gland development]
GO:0021998 [neural plate mediolateral regionalization]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0030425 [dendrite]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0035137 [hindlimb morphogenesis]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042733 [embryonic digit morphogenesis]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048339 [paraxial mesoderm development]
GO:0048352 [paraxial mesoderm structural organization]
GO:0048368 [lateral mesoderm development]
GO:0048378 [regulation of lateral mesodermal cell fate specification]
GO:0048382 [mesendoderm development]
GO:0048568 [embryonic organ development]
GO:0048589 [developmental growth]
GO:0048598 [embryonic morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050768 [negative regulation of neurogenesis]
GO:0051216 [cartilage development]
GO:0060021 [palate development]
GO:0060391 [positive regulation of SMAD protein import into nucleus]
GO:0060896 [neural plate pattern specification]
GO:0060914 [heart formation]
GO:0071773 [cellular response to BMP stimulus]
GO:1990712 [HFE-transferrin receptor complex]
GO:2000772 [regulation of cellular senescence]
Show all
532 aa
60.2 kDa
Yes 1
BMPR1A-003
ENSP00000483569
ENST00000480152
A0A087X0P8 [Direct mapping]
Bone morphogenetic protein receptor type-1A
Show all
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
41 aa
4.7 kDa
No 0

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