Cell atlas - ACBD5 - The Human Protein Atlas

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ACBD5

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Peroxisomes

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	ACBD5
Gene description	Acyl-CoA binding domain containing 5
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the peroxisome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Peroxisomes (validated)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA011861 , HPA012145
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the peroxisome.

Main location

Peroxisomes (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA011861	A-431	Peroxisomes
	HPA011861	U-2 OS	Nucleoplasm
	HPA011861	U-2 OS	Peroxisomes
	HPA011861	U-251 MG	Peroxisomes
	HPA012145	A-431	Nucleus
	HPA012145	A-431	Peroxisomes
	HPA012145	U-2 OS	Nucleoplasm
	HPA012145	U-2 OS	Peroxisomes
	HPA012145	U-251 MG	Nucleoplasm
	HPA012145	U-251 MG	Peroxisomes

CUSTOM DATA


	Toggle channels

Thumbnail	Antibody	Cell line	Assay	Description
	HPA011861	U-2 OS	Image	ACBD5 localizes to peroxisomes, as it co-localizes with the peroxisomal marker ABCD3.
	HPA012145	U-2 OS	Image	ACBD5 localizes to peroxisomes, as it co-localizes with the peroxisomal marker ABCD3.

MOUSE CELLS

Main location

Vesicles

Additional location

Nucleus, Nucleoli

Mouse gene

ENSMUSG00000026781 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA011861	NIH 3T3	Nucleus
			Nucleoli
			Vesicles

GENE INFORMATION
Gene name	ACBD5 (HGNC Symbol)
Synonyms	DKFZp434A2417, KIAA1996
Description	Acyl-CoA binding domain containing 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	10
Cytoband	p12.1
Chromosome location (bp)	27195214 - 27242130
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107897 (version 83.38)
Entrez gene	91452
UniProt	Q5T8D3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T8D3
Antibodypedia	ACBD5 antibodies

PROTEIN BROWSER

ACBD5-001	ACBD5-002	ACBD5-003	ACBD5-005	ACBD5-006	ACBD5-007	ACBD5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACBD5-001 ENSP00000379568 ENST00000396271	Q5T8D3 [Direct mapping] Acyl-CoA-binding domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0006810 [transport] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030242 [pexophagy] GO:0043231 [intracellular membrane-bounded organelle] Show all	525 aa 59 kDa	No	1
ACBD5-002 ENSP00000365070 ENST00000375905	Q5T8D3 [Direct mapping] Acyl-CoA-binding domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0006810 [transport] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030242 [pexophagy] GO:0043231 [intracellular membrane-bounded organelle] Show all	490 aa 54.8 kDa	No	1
ACBD5-003 ENSP00000365066 ENST00000375901	Q5T8D3 [Direct mapping] Acyl-CoA-binding domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0006810 [transport] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030242 [pexophagy] GO:0043231 [intracellular membrane-bounded organelle] Show all	416 aa 46.3 kDa	No	1
ACBD5-005 ENSP00000365049 ENST00000375888	Q5T8D3 [Direct mapping] Acyl-CoA-binding domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0006810 [transport] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030242 [pexophagy] GO:0043231 [intracellular membrane-bounded organelle] Show all	534 aa 60.1 kDa	No	1
ACBD5-006 ENSP00000401591 ENST00000426079	Q5T8E0 [Direct mapping] Acyl-CoA-binding domain-containing protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] Show all	252 aa 28.2 kDa	No	0
ACBD5-007 ENSP00000393398 ENST00000412279	X6RDD7 [Direct mapping] Acyl-CoA-binding domain-containing protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] Show all	251 aa 28.1 kDa	No	0
ACBD5-201 ENSP00000365062 ENST00000375897	B7Z2R7 [Direct mapping] Acyl-CoA-binding domain-containing protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000062 [fatty-acyl-CoA binding] GO:0006810 [transport] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] Show all	523 aa 58.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.