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ACBD5

GENERAL INFORMATION

Gene name

 ACBD5

Gene description

 Acyl-CoA binding domain containing 5

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA011861 , HPA012145
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011861
HPA012145

GENE INFORMATION

Gene name

 ACBD5 (HGNC Symbol)

Synonyms

 DKFZp434A2417, KIAA1996

Description

 Acyl-CoA binding domain containing 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 10

Cytoband

 p12.1

Chromosome location (bp)

 27195214 - 27242130

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107897 (version 83.38)

Entrez gene

 91452

UniProt

 Q5T8D3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5T8D3

Antibodypedia

 ACBD5 antibodies

PROTEIN BROWSER
ACBD5-001
ACBD5-002
ACBD5-003
ACBD5-005
ACBD5-006
ACBD5-007
ACBD5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACBD5-001
ENSP00000379568
ENST00000396271
Q5T8D3 [Direct mapping]
Acyl-CoA-binding domain-containing protein 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003674 [molecular_function]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030242 [pexophagy]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 525 aa
59 kDa 		No 1
ACBD5-002
ENSP00000365070
ENST00000375905
Q5T8D3 [Direct mapping]
Acyl-CoA-binding domain-containing protein 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003674 [molecular_function]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030242 [pexophagy]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 490 aa
54.8 kDa 		No 1
ACBD5-003
ENSP00000365066
ENST00000375901
Q5T8D3 [Direct mapping]
Acyl-CoA-binding domain-containing protein 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003674 [molecular_function]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030242 [pexophagy]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 416 aa
46.3 kDa 		No 1
ACBD5-005
ENSP00000365049
ENST00000375888
Q5T8D3 [Direct mapping]
Acyl-CoA-binding domain-containing protein 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003674 [molecular_function]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005777 [peroxisome]
GO:0005778 [peroxisomal membrane]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030242 [pexophagy]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 534 aa
60.1 kDa 		No 1
ACBD5-006
ENSP00000401591
ENST00000426079
Q5T8E0 [Direct mapping]
Acyl-CoA-binding domain-containing protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
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 252 aa
28.2 kDa 		No 0
ACBD5-007
ENSP00000393398
ENST00000412279
X6RDD7 [Direct mapping]
Acyl-CoA-binding domain-containing protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
Show all
 251 aa
28.1 kDa 		No 0
ACBD5-201
ENSP00000365062
ENST00000375897
B7Z2R7 [Direct mapping]
Acyl-CoA-binding domain-containing protein 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0006810 [transport]
GO:0008289 [lipid binding]
GO:0016021 [integral component of membrane]
Show all
 523 aa
58.8 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.