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GTPBP4

GENERAL INFORMATION

Gene name

 GTPBP4

Gene description

 GTP binding protein 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nucleolar expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA039618
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039618

GENE INFORMATION

Gene name

 GTPBP4 (HGNC Symbol)

Synonyms

 CRFG, FLJ10686, FLJ10690, NGB, NOG1

Description

 GTP binding protein 4 (HGNC Symbol)

Entrez gene summary

 GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p15.3

Chromosome location (bp)

 988019 - 1019936

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107937 (version 83.38)

Entrez gene

 23560

UniProt

 Q9BZE4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZE4

Antibodypedia

 GTPBP4 antibodies

PROTEIN BROWSER
GTPBP4-001
GTPBP4-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GTPBP4-001
ENSP00000354040
ENST00000360803
Q9BZE4 [Direct mapping]
Nucleolar GTP-binding protein 1
D2CFK9 [Target identity:100%; Query identity:100%]
Nucleolar GTP-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0001649 [osteoblast differentiation]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0016020 [membrane]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030336 [negative regulation of cell migration]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031965 [nuclear membrane]
GO:0033342 [negative regulation of collagen binding]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050821 [protein stabilization]
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 634 aa
74 kDa 		No 0
GTPBP4-006
ENSP00000353168
ENST00000360059
Q5T3R7 [Direct mapping]
Nucleolar GTP-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 140 aa
16.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.