Expression of MTPAP in cancer - Summary - The Human Protein Atlas

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MTPAP

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MTPAP
Gene description	Mitochondrial poly(A) polymerase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA038620
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038620

GENE INFORMATION
Gene name	MTPAP (HGNC Symbol)
Synonyms	FLJ10486, mtPAP, PAPD1, SPAX4
Description	Mitochondrial poly(A) polymerase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]
Chromosome	10
Cytoband	p11.23
Chromosome location (bp)	30309801 - 30374448
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000107951 (version 83.38)
Entrez gene	55149
UniProt	Q9NVV4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVV4
Antibodypedia	MTPAP antibodies

PROTEIN BROWSER

MTPAP-001	MTPAP-003	MTPAP-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MTPAP-001 ENSP00000263063 ENST00000263063	Q9NVV4 [Direct mapping] Poly(A) RNA polymerase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0002134 [UTP binding] GO:0004652 [polynucleotide adenylyltransferase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006351 [transcription, DNA-templated] GO:0006378 [mRNA polyadenylation] GO:0030145 [manganese ion binding] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0071044 [histone mRNA catabolic process] Show all	582 aa 66.2 kDa	No	0
MTPAP-003 ENSP00000404392 ENST00000417581	Q5T852 [Direct mapping] Poly(A) RNA polymerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0043231 [intracellular membrane-bounded organelle] Show all	219 aa 25.3 kDa	No	0
MTPAP-004 ENSP00000394118 ENST00000421701	Q5T851 [Direct mapping] Poly(A) RNA polymerase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0043231 [intracellular membrane-bounded organelle] Show all	150 aa 17.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.