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MTPAP

GENERAL INFORMATION

Gene name

 MTPAP

Gene description

 Mitochondrial poly(A) polymerase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Tissue enriched (testis)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA038620
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MTPAP (HGNC Symbol)

Synonyms

 FLJ10486, mtPAP, PAPD1, SPAX4

Description

 Mitochondrial poly(A) polymerase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]

Chromosome

 10

Cytoband

 p11.23

Chromosome location (bp)

 30309801 - 30374448

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000107951 (version 83.38)

Entrez gene

 55149

UniProt

 Q9NVV4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NVV4

Antibodypedia

 MTPAP antibodies

PROTEIN BROWSER
MTPAP-001
MTPAP-003
MTPAP-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTPAP-001
ENSP00000263063
ENST00000263063
Q9NVV4 [Direct mapping]
Poly(A) RNA polymerase, mitochondrial
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002134 [UTP binding]
GO:0004652 [polynucleotide adenylyltransferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0006378 [mRNA polyadenylation]
GO:0030145 [manganese ion binding]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044822 [poly(A) RNA binding]
GO:0071044 [histone mRNA catabolic process]
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 582 aa
66.2 kDa 		No 0
MTPAP-003
ENSP00000404392
ENST00000417581
Q5T852 [Direct mapping]
Poly(A) RNA polymerase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0043231 [intracellular membrane-bounded organelle]
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 219 aa
25.3 kDa 		No 0
MTPAP-004
ENSP00000394118
ENST00000421701
Q5T851 [Direct mapping]
Poly(A) RNA polymerase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 150 aa
17.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.