Cell atlas - SHOC2 - The Human Protein Atlas

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SHOC2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SHOC2
Gene description	SHOC2 leucine-rich repeat scaffold protein
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (supported)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA009164
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA009164	A-431	Nucleoplasm
	HPA009164	A-431	Cytosol
	HPA009164	U-2 OS	Nucleoplasm
	HPA009164	U-2 OS	Cytosol
	HPA009164	U-251 MG	Nucleoplasm
	HPA009164	U-251 MG	Cytosol

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000024976 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA009164	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	SHOC2 (HGNC Symbol)
Synonyms	KIAA0862, SOC-2, SOC2, SUR-8, SUR8
Description	SHOC2 leucine-rich repeat scaffold protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]
Chromosome	10
Cytoband	q25.2
Chromosome location (bp)	110919547 - 111013667
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108061 (version 83.38)
Entrez gene	8036
UniProt	Q9UQ13 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UQ13
Antibodypedia	SHOC2 antibodies

PROTEIN BROWSER

SHOC2-001	SHOC2-002	SHOC2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SHOC2-001 ENSP00000358464 ENST00000369452	Q9UQ13 [Direct mapping] Leucine-rich repeat protein SHOC-2 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000164 [protein phosphatase type 1 complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007265 [Ras protein signal transduction] GO:0008157 [protein phosphatase 1 binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019888 [protein phosphatase regulator activity] GO:0019903 [protein phosphatase binding] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0050790 [regulation of catalytic activity] Show all	582 aa 64.9 kDa	No	0
SHOC2-002 ENSP00000408275 ENST00000451838	X6RI37 [Direct mapping] Leucine-rich repeat protein SHOC-2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	372 aa 41.9 kDa	No	0
SHOC2-201 ENSP00000265277 ENST00000265277	Q9UQ13 [Direct mapping] Leucine-rich repeat protein SHOC-2 Show all	Predicted intracellular proteins Plasma proteins RAS pathway related proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000164 [protein phosphatase type 1 complex] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007265 [Ras protein signal transduction] GO:0008157 [protein phosphatase 1 binding] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019888 [protein phosphatase regulator activity] GO:0019903 [protein phosphatase binding] GO:0046579 [positive regulation of Ras protein signal transduction] GO:0050790 [regulation of catalytic activity] Show all	536 aa 59.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.