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SHOC2

GENERAL INFORMATION

Gene name

 SHOC2

Gene description

 SHOC2 leucine-rich repeat scaffold protein

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending reevaluation.

Reliability score

 Uncertain based on 1 antibody.
HPA009164
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA009164

GENE INFORMATION

Gene name

 SHOC2 (HGNC Symbol)

Synonyms

 KIAA0862, SOC-2, SOC2, SUR-8, SUR8

Description

 SHOC2 leucine-rich repeat scaffold protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010]

Chromosome

 10

Cytoband

 q25.2

Chromosome location (bp)

 110919547 - 111013667

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108061 (version 83.38)

Entrez gene

 8036

UniProt

 Q9UQ13 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UQ13

Antibodypedia

 SHOC2 antibodies

PROTEIN BROWSER
SHOC2-001
SHOC2-002
SHOC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SHOC2-001
ENSP00000358464
ENST00000369452
Q9UQ13 [Direct mapping]
Leucine-rich repeat protein SHOC-2
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Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000164 [protein phosphatase type 1 complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007265 [Ras protein signal transduction]
GO:0008157 [protein phosphatase 1 binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019888 [protein phosphatase regulator activity]
GO:0019903 [protein phosphatase binding]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0050790 [regulation of catalytic activity]
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 582 aa
64.9 kDa 		No 0
SHOC2-002
ENSP00000408275
ENST00000451838
X6RI37 [Direct mapping]
Leucine-rich repeat protein SHOC-2
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 372 aa
41.9 kDa 		No 0
SHOC2-201
ENSP00000265277
ENST00000265277
Q9UQ13 [Direct mapping]
Leucine-rich repeat protein SHOC-2
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Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000164 [protein phosphatase type 1 complex]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007265 [Ras protein signal transduction]
GO:0008157 [protein phosphatase 1 binding]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0019888 [protein phosphatase regulator activity]
GO:0019903 [protein phosphatase binding]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0050790 [regulation of catalytic activity]
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 536 aa
59.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.