Expression of GIT1 in cancer - Summary - The Human Protein Atlas

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GIT1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GIT1
Gene description	G protein-coupled receptor kinase interacting ArfGAP 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA004059 , HPA004186
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004059	HPA004186

GENE INFORMATION
Gene name	GIT1
Synonyms
Description	G protein-coupled receptor kinase interacting ArfGAP 1 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q11.2
Chromosome location (bp)	29573469 - 29594054
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108262 (version 83.38)
Entrez gene	28964
UniProt	Q9Y2X7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2X7
Antibodypedia	GIT1 antibodies

PROTEIN BROWSER

GIT1-001	GIT1-003	GIT1-006	GIT1-008	GIT1-011	GIT1-012	GIT1-015	GIT1-016	GIT1-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GIT1-001 ENSP00000225394 ENST00000225394	Q9Y2X7 [Direct mapping] ARF GTPase-activating protein GIT1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0007411 [axon guidance] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016020 [membrane] GO:0016235 [aggresome] GO:0032465 [regulation of cytokinesis] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0048013 [ephrin receptor signaling pathway] Show all	761 aa 84.3 kDa	No	0
GIT1-003 ENSP00000378338 ENST00000394869	Q9Y2X7 [Direct mapping] ARF GTPase-activating protein GIT1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0007411 [axon guidance] GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway] GO:0016020 [membrane] GO:0016235 [aggresome] GO:0032403 [protein complex binding] GO:0032465 [regulation of cytokinesis] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0048013 [ephrin receptor signaling pathway] Show all	770 aa 85.4 kDa	No	0
GIT1-006 ENSP00000464388 ENST00000579937	J3QRU8 [Direct mapping] ARF GTPase-activating protein GIT1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0016235 [aggresome] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] Show all	694 aa 76.8 kDa	No	0
GIT1-008 ENSP00000462775 ENST00000581348	A0A0C4DGN6 [Direct mapping] ARF GTPase-activating protein GIT1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0043547 [positive regulation of GTPase activity] Show all	747 aa 83.1 kDa	No	0
GIT1-011 ENSP00000334125 ENST00000335356	E7EVC2 [Direct mapping] ARF GTPase-activating protein GIT1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		147 aa 15.4 kDa	No	0
GIT1-012 ENSP00000464933 ENST00000577466	K7EIX6 [Direct mapping] ARF GTPase-activating protein GIT1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.9 kDa	No	0
GIT1-015 ENSP00000466824 ENST00000583413	K7EN79 [Direct mapping] ARF GTPase-activating protein GIT1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0043547 [positive regulation of GTPase activity] Show all	173 aa 19.2 kDa	No	0
GIT1-016 ENSP00000463543 ENST00000585148	J3QLH1 [Direct mapping] ARF GTPase-activating protein GIT1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		229 aa 25.8 kDa	No	0
GIT1-017 ENSP00000463435 ENST00000578266	J3QL89 [Direct mapping] ARF GTPase-activating protein GIT1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] Show all	177 aa 19 kDa	No	0

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The Human Protein Atlas

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