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UBTF

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GENERAL INFORMATION

Gene name

 UBTF

Gene description

 Upstream binding transcription factor, RNA polymerase I

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli (fibrillar center).

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli fibrillar center (validated)

siRNA

 The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB004611 , HPA006385
SHOW MORE

ASSAYS
RNA expression
Human cells
siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli (fibrillar center).

Main location

 Nucleoli fibrillar center (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB004611 A-431 Nucleus
Nucleoli fibrillar center
CAB004611 U-2 OS Nucleoli fibrillar center
CAB004611 U-251 MG No staining    
HPA006385 A-431 Nucleoli fibrillar center
HPA006385 U-2 OS Nucleoli fibrillar center
HPA006385 U-251 MG Nucleoli fibrillar center

siRNA VALIDATION

Antibody

 HPA006385

siRNA validation

 Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

 Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

 18%14%

p-value

 < 0.01< 0.01
 

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail 10x

Thumbnail 40x

Antibody

Sample

Cell line
HPA006385 siRNA 1 U-2 OS
HPA006385 siRNA 2 U-2 OS
HPA006385 scrambled U-2 OS

GENE INFORMATION

Gene name

 UBTF (HGNC Symbol)

Synonyms

 NOR-90, UBF, UBF1, UBF2

Description

 Upstream binding transcription factor, RNA polymerase I (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11. [provided by RefSeq, Aug 2011]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 44205033 - 44221626

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108312 (version 83.38)

Entrez gene

 7343

UniProt

 P17480 (UniProt - Evidence at protein level)

neXtProt

 NX_P17480

Antibodypedia

 UBTF antibodies

PROTEIN BROWSER
UBTF-001
UBTF-002
UBTF-004
UBTF-005
UBTF-006
UBTF-007
UBTF-008
UBTF-009
UBTF-011
UBTF-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBTF-001
ENSP00000345297
ENST00000343638
P17480 [Direct mapping]
Nucleolar transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044822 [poly(A) RNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
Show all
 727 aa
84.9 kDa 		No 0
UBTF-002
ENSP00000302640
ENST00000302904
P17480 [Direct mapping]
Nucleolar transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000183 [chromatin silencing at rDNA]
GO:0001650 [fibrillar center]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044822 [poly(A) RNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
Show all
 764 aa
89.4 kDa 		No 0
UBTF-004
ENSP00000377231
ENST00000393606
P17480 [Direct mapping]
Nucleolar transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044822 [poly(A) RNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
Show all
 727 aa
84.9 kDa 		No 0
UBTF-005
ENSP00000390669
ENST00000436088
P17480 [Direct mapping]
Nucleolar transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044822 [poly(A) RNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
Show all
 764 aa
89.4 kDa 		No 0
UBTF-006
ENSP00000437180
ENST00000533177
P17480 [Direct mapping]
Nucleolar transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044822 [poly(A) RNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
Show all
 727 aa
84.9 kDa 		No 0
UBTF-007
ENSP00000432925
ENST00000526094
P17480 [Direct mapping]
Nucleolar transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044822 [poly(A) RNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
Show all
 727 aa
84.9 kDa 		No 0
UBTF-008
ENSP00000435708
ENST00000529383
P17480 [Direct mapping]
Nucleolar transcription factor 1
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
GO:0006356 [regulation of transcription from RNA polymerase I promoter]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0010467 [gene expression]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0044822 [poly(A) RNA binding]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045943 [positive regulation of transcription from RNA polymerase I promoter]
Show all
 764 aa
89.4 kDa 		No 0
UBTF-009
ENSP00000433046
ENST00000530828
E9PMM2 [Direct mapping]
Nucleolar transcription factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0006338 [chromatin remodeling]
Show all
 149 aa
17.8 kDa 		No 0
UBTF-011
ENSP00000431295
ENST00000529373
E9PLT2 [Direct mapping]
Nucleolar transcription factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0006338 [chromatin remodeling]
Show all
 194 aa
23 kDa 		No 0
UBTF-014
ENSP00000431539
ENST00000527034
E9PKP7 [Direct mapping]
Nucleolar transcription factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003682 [chromatin binding]
GO:0005730 [nucleolus]
GO:0006338 [chromatin remodeling]
Show all
 745 aa
87.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.