Expression of RAPGEFL1 in cancer - Summary - The Human Protein Atlas

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RAPGEFL1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	RAPGEFL1
Gene description	Rap guanine nucleotide exchange factor (GEF)-like 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	RAPGEFL1 (HGNC Symbol)
Synonyms	Link-GEFII
Description	Rap guanine nucleotide exchange factor (GEF)-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q21.1
Chromosome location (bp)	40177010 - 40195656
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108352 (version 83.38)
Entrez gene	51195
UniProt	Q9UHV5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHV5
Antibodypedia	RAPGEFL1 antibodies

PROTEIN BROWSER

RAPGEFL1-001	RAPGEFL1-004	RAPGEFL1-005	RAPGEFL1-006	RAPGEFL1-007	RAPGEFL1-008	RAPGEFL1-011	RAPGEFL1-012	RAPGEFL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RAPGEFL1-001 ENSP00000484772 ENST00000613811	A0A087X280 [Direct mapping] Rap guanine nucleotide exchange factor-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	459 aa 49.8 kDa	No	0
RAPGEFL1-004 ENSP00000438631 ENST00000544503	F5H2D5 [Direct mapping] Rap guanine nucleotide exchange factor-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	505 aa 58 kDa	No	0
RAPGEFL1-005 ENSP00000394530 ENST00000456989	Q9UHV5 [Direct mapping] Rap guanine nucleotide exchange factor-like 1 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007399 [nervous system development] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] Show all	511 aa 58.8 kDa	No	0
RAPGEFL1-006 ENSP00000440006 ENST00000538884	F5GY17 [Direct mapping] Rap guanine nucleotide exchange factor-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		20 aa 2.2 kDa	No	0
RAPGEFL1-007 ENSP00000264644 ENST00000264644	Q9UHV5 [Direct mapping] Rap guanine nucleotide exchange factor-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007399 [nervous system development] GO:0016020 [membrane] GO:0043547 [positive regulation of GTPase activity] Show all	456 aa 52.3 kDa	No	0
RAPGEFL1-008 ENSP00000441059 ENST00000538981	F5GXC6 [Direct mapping] Rap guanine nucleotide exchange factor-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		101 aa 11.8 kDa	No	0
RAPGEFL1-011 ENSP00000440226 ENST00000543876	F5GYJ3 [Direct mapping] Rap guanine nucleotide exchange factor-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005057 [receptor signaling protein activity] GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0035556 [intracellular signal transduction] Show all	149 aa 17.2 kDa	No	0
RAPGEFL1-012 ENSP00000444646 ENST00000541245	F5H582 [Direct mapping] Rap guanine nucleotide exchange factor-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 7.1 kDa	No	0
RAPGEFL1-201 ENSP00000479735 ENST00000620260	A0A087WVW6 [Direct mapping] Rap guanine nucleotide exchange factor-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	662 aa 73.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.