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RGS9

GENERAL INFORMATION

Gene name

 RGS9

Gene description

 Regulator of G-protein signaling 9

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (HDLM-2, HEL)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in photoreceptors in retina.

ANTIBODY IHC RELIABILITY

Data reliability
description

 No internal RNA expression data available for correlation. External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA014137
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA014137

GENE INFORMATION

Gene name

 RGS9 (HGNC Symbol)

Synonyms

 MGC111763, MGC26458, PERRS, RGS9L

Description

 Regulator of G-protein signaling 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RGS family of GTPase activating proteins that function in various signaling pathways by accelerating the deactivation of G proteins. This protein is anchored to photoreceptor membranes in retinal cells and deactivates G proteins in the rod and cone phototransduction cascades. Mutations in this gene result in bradyopsia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Chromosome

 17

Cytoband

 q24.1

Chromosome location (bp)

 65137431 - 65227703

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108370 (version 83.38)

Entrez gene

 8787

UniProt

 O75916 (UniProt - Evidence at protein level)

neXtProt

 NX_O75916

Antibodypedia

 RGS9 antibodies

PROTEIN BROWSER
RGS9-002
RGS9-003
RGS9-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGS9-002
ENSP00000396329
ENST00000449996
O75916 [Direct mapping]
Regulator of G-protein signaling 9
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0004871 [signal transducer activity]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
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 671 aa
76.6 kDa 		No 0
RGS9-003
ENSP00000262406
ENST00000262406
O75916 [Direct mapping]
Regulator of G-protein signaling 9
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0004871 [signal transducer activity]
GO:0005096 [GTPase activator activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007212 [dopamine receptor signaling pathway]
GO:0007399 [nervous system development]
GO:0007601 [visual perception]
GO:0007603 [phototransduction, visible light]
GO:0008277 [regulation of G-protein coupled receptor protein signaling pathway]
GO:0009968 [negative regulation of signal transduction]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0032403 [protein complex binding]
GO:0035556 [intracellular signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0043627 [response to estrogen]
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 674 aa
77 kDa 		No 0
RGS9-007
ENSP00000405814
ENST00000443584
E9PD91 [Direct mapping]
Regulator of G-protein-signaling 9
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0005737 [cytoplasm]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0035556 [intracellular signal transduction]
Show all
 628 aa
72 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.