Cell atlas - ASPA - The Human Protein Atlas

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ASPA

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ASPA
Gene description	Aspartoacylase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (CACO-2, ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA022145
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CACO-2, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA022145	A-431	Cytosol
	HPA022145	U-2 OS	Cytosol
	HPA022145	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ASPA (HGNC Symbol)
Synonyms	ACY2, ASP
Description	Aspartoacylase (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	3472374 - 3503419
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108381 (version 83.38)
Entrez gene	443
UniProt	P45381 (UniProt - Evidence at protein level)
neXtProt	NX_P45381
Antibodypedia	ASPA antibodies

PROTEIN BROWSER

ASPA-001	ASPA-002	ASPA-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASPA-001 ENSP00000263080 ENST00000263080	P45381 [Direct mapping] Aspartoacylase Q6FH48 [Target identity:100%; Query identity:100%] ASPA protein; Aspartoacylase (Canavan disease), isoform CRA_a; cDNA, FLJ93347, Homo sapiens aspartoacylase (aminoacylase 2, Canavan disease)(ASPA), mRNA Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004046 [aminoacylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006533 [aspartate catabolic process] GO:0008152 [metabolic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0019807 [aspartoacylase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	313 aa 35.7 kDa	No	0
ASPA-002 ENSP00000409976 ENST00000456349	P45381 [Direct mapping] Aspartoacylase Q6FH48 [Target identity:100%; Query identity:100%] ASPA protein; Aspartoacylase (Canavan disease), isoform CRA_a; cDNA, FLJ93347, Homo sapiens aspartoacylase (aminoacylase 2, Canavan disease)(ASPA), mRNA Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004046 [aminoacylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006533 [aspartate catabolic process] GO:0008152 [metabolic process] GO:0008652 [cellular amino acid biosynthetic process] GO:0016788 [hydrolase activity, acting on ester bonds] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0019807 [aspartoacylase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	313 aa 35.7 kDa	No	0
ASPA-003 ENSP00000458324 ENST00000577034	I3L0T3 [Direct mapping] Aspartoacylase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0008152 [metabolic process] GO:0016788 [hydrolase activity, acting on ester bonds] Show all	79 aa 8.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.